Effect of Several Hydrophilic Polymers on the Permeation of Morphine and Salicylic Acid through Excised Hairless Rat Skin
スポンサーリンク
概要
- 論文の詳細を見る
Several hydrophilic polymers changed the cumulative amount of morphine (MOR) permeated through excised hairless rat skin from 1% MOR hydrochloride solution containing ethanol and l-menthol at concentration of 40% and 5%, respectively, as permeation enhancers, Anionic polymers (carboxyvinylpolymer and methylvinylether-maleic anhydride copolymer) in the test solutions decreased the skin permeation of MOR, whereas cationic polymers (polyethyleneimine and chitosan) increased it, compared with that without polymers. Little change, however, was observed by the addition of nonionic polymers (ydroxypropylcellulose and polyethyleneoxide). ON the other hand, the cationic and anionic polymers in the test solutions decreased and increase, respectively the skin permeation of salicyclic acid (SA) from the same enhancing system containing sodium salicylate. These opposite results were probably caused by the change in escaping tendency of the drugs from the vehicles, which was due to the drug-polymer interaction. (The escaping tendency has a great effect on the drug partition from the polymer solution to the skin barrier). The effect of hydrophilic polymers on the partition was then evaluated by Donnan membrane theory. The partition of MOR was increased and decreased by the presence of polymers having identical and opposite charge to MOR. The low partition of the drugs to skin may also be caused by low diffusion of the drugs in the polymer solutions. The drug release from the hydrophilic polymer solutions was then measured, and the release rate was found to have decreased in the presence of polymers having opposite charge to MOR and SA. It is suggested that these drug-polymer interactions changed the drug partition to skin thus changing the skin permeation of the drug.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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Wada Yoshio
Research Institute of TTS Technology
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Sano Motohiko
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University:faculty Of Pharmac
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Hosoya Osamu
Research Institute of TTS Technology
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Seki Toshinobu
Research Institute of TTS Technology
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Juni Kazuhiko
Faculty of Pharmaceutical Sciences, Josai University
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Wada Y
Faculty Of Pharmaceutical Sciences Research Institute Of Tts Technology
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Hosoya O
Department Of Pharmacy Japanese Red Cross Hospital Omori
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Hosoya O
Niigata Univ. Niigata Jpn
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Hosoya Osamu
Research Institute Of Tts Technology Josai University
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Juni K
Faculty Of Pharmaceutical Sciences Josai University
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Juni Kazuhiko
北海道薬科大学
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Juni Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Morimoto Y
Josai Univ. Saitama Jpn
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
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SANO Motohiko
Faculty of Pharmaceutical Sciences, Josai University
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SUGIBAYASHI Kenji
Research Institute of TTS Technology
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MORIMOTO Yasunori
Research Institute of TTS Technology
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Faculty Of Pharmaceutial Sciences Josai University
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Sugibayashi Kenji
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Fac. Of Pharmaceutical Sciences Josai Univ.
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Sugibayashi Kenji
Josai-university Faculty Of Pharmaceutical Sciences
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Sugibayashi Kenji
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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Sano M
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University:faculty Of Pharmac
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Sugibayashi K
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
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Wada Y
Yakult Central Institute For Microbiological Research
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SUGIE Kenichi
Josai-University faculty of pharmaceutical sciences
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