Behavior of Propylene Glycol (PG) in Dermis after Treatment of Rat Intact Skin Surface with Fatty Acids, Fatty Amines or Azone Dissolved in PG
スポンサーリンク
概要
- 論文の詳細を見る
Rat abdominal intact skin was treated with fatty acids, fatty amines, or Azone which were dissolved in propylene glycol (PG) and PG appearing in the rat dermis was studied. Analysis was done by Fourier transform infrared/attenuated total reflection (FT-IR/ATR) spectroscopy. The appearance of PG with time seemed to be in three phases when the skin sample was treated with a skin penetration enhancer such as oleic acid : (1) in the first stage, PG penetrated the skin barrier which was not substantially altered, and gradually appeared in the dermis ; (2) in the second stage, it rapidly distributed in/throughout the dermis, and this rapid distribution was probably due to the alteration of the dermal structure : the penetration enhancing effect of the enhancer was thought to reach maximal ; and (3) in the third stage, PG was saturated in the dermis. The value of T_<max alteration>, at which the alteration of the dermal structures is completed, showed that the action of both oleic acid and oleylamine were more rapid than other enhancers. Both the value of PG peak area_<max> at the third stage which reflects the distribution volume of PG in the dermis and the value of T_<sat> at which PG is saturated in the dermis were calculated, and the results suggested that both the distribution volume of PG in the dermis and the time of the saturation varied depending on the enhancer. In conclusion, our present work indicated the importance and necessity of evaluating the rate and extent of appearance of a drug in the dermis to characterize an enhancer. The dermis was also suggested to act as the skin barrier to drug penetration.
- 社団法人日本薬学会の論文
- 1995-02-15
著者
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福島 昭二
Department Of Pharmacy Kumamoto University Hospital Faculty Of Pharmaceutical Sciences Kobe-gakuin U
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山岡 由美子
神戸学院大学薬学部
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竹内 由和
神戸学院大学薬学部臨床薬学部門薬剤学研究室
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福島 昭二
神戸学院大学薬学部薬剤学講座
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竹内 由和
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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山岡 由美子
Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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安川 秀仁
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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森本 泰子
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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田口 賢二
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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下仲 康弘
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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西永 浩子
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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西永 浩子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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竹内 由和
Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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田口 賢二
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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下仲 康弘
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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安川 秀仁
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Morimoto Y
Josai Univ. Saitama Jpn
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Yasukawa Hidehito
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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