Coating of Pharmaceutical Powders by Fluidized Bed Process. III. : Aqueous Coating with Ethyl Acrylate-Methyl Methacrylate-2-Hydroxyethyl Methacrylate Copolymer and the Dissolution Properties of the Products
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概要
- 論文の詳細を見る
Aqueous dispersions of ethyl acrylate (EA)-methyl methacrylate (MMA)-2-hydroxyethyl methacrylate (HEMA) copolymers were developed to produce microcapsules with a pH-independently water-insoluble membrane by the Wurster process. The dispersions were prepared by an emulsion polymerization technique. The resin dry weight content of the dispersion was 21-23%. Lactose (328μm) and phenacetin were used as drug models.The mole ratios of EA, MMA and HEMA used were 12 : 6 : X, 9 : 9 : X and 6 : 12 : X (X=4,6,8). An incrase in MMA content raised the softening temperature of the membrane. HEMA affected it far less than MMA, but remarkably enhanced the release of lactose in JPXI disintegration 2nd fluid (pH 6.8).The delayed release of lactose, characterized by a lag time and subsequent rapid release, was observed most clearly for the microcapsules prepared with EA-MMA-HEMA (9 : 9 : 4) copolymer. When the lactose microcapsules contained phenacetin and polyvinylpyrrolidone (PVP), PVP did not affect the lag time, but remarkably enhanced the release of lactose after the lag time. Phenacetin was also released in a similar manner.From the expansion of the particles in the dissolution fluid, it was estimated that the lag time corresponded to the time needed for the membrane to be hydrated, and the subsequent rapid release resulted from the permeability change caused by hydration and the reduction in membrane thickness due to the particle expansion by taken-up water. Polyvinylpyrrolidone contained within microcapsules enhanced the water intake, which induced bursing ofthe membrane.
- 社団法人日本薬学会の論文
- 1988-08-25
著者
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竹内 由和
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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山岡 由美子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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福田 友昭
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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福森 義信
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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市川 秀喜
神戸学院大学薬学部
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市川 秀喜
神戸学院大学薬学部物性薬学部門製剤学研究室 同ライフサイエンス産学連携研究センター
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竹内 由和
神戸学院大学薬学部臨床薬学部門薬剤学研究室
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山岡 由美子
Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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市川 秀喜
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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大迫 義文
Fuji Paudal
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竹内 由和
Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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福森 義信
神戸学院大学 薬学部
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福田 友昭
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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竹内 由和
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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山岡 由美子
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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大迫 義文
不二パウダル(株)開発部
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市川 秀喜
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin University
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