Effects of Fatty Acids, Fatty Amines and Propylene Glycol on Rat Stratum Corneum Lipids and Proteins in Vitro Measured by Fourier Transform Infrared/Attenuated Total Reflection (FT-IR/ATR) Spectroscopy

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概要

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• Fourier transform infrared/attenuated total reflection (FT-IR/ATR) spectroscopy was used to examine the effect of fatty acids, fatty amines and propylene glycol (PG) on the molecular mobility of rat stratum corneum lipids and keratinized proteins, using a hydrophobic solute, indomethacin, and a polar solute, 5- and 6-carboxyfluorescein (CF). Treatment of the skin with either oleic acid or oleylamine resulted in significant CH_2 C-H asymmetric stretching band shifts and broadening. The extent of spectral alteration varied with the chemical structure of the penetrant. The penetrants increased the lipophilic indomethacin flux and shortened the lag times through the skin in vitro. The plot of frequency changes vs. indomethacin flux or lag time demonstrated a linear relationship, thus indicating that spectral alteration in CH_2 C-H stretching regions of stratum corneum lipids may provide a reliable index for characterizing penetrants. The data also showed that the hydrophilic group which attached to the CH_2 group in the penetrant molecules did not play a part in the membrane permeability enhancing action. Oleic acid and oleylamine appeared to induce a conformational alteration of the keratinized proteins from α-helix to beta sheet. Such alteration was also observed with PG treatment. Accumulation of CF was significantly increased by the PG pretreatment of the skin, thus suggesting that PG-induced protein conformational changes could be related to the enhancement of CF accumulation.

• 社団法人日本薬学会の論文
• 1992-07-25

著者

• 竹内 洋文

  50周年誌編集小委員会

• 福田 友昭

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 加藤 裕一

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• 山岡 由美子

  神戸学院大学薬学部

• 竹内 由和

  神戸学院大学薬学部臨床薬学部門薬剤学研究室

• 山岡 由美子

  Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 竹内 洋文

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 安川 秀仁

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 森本 泰子

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 福森 義信

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 福田 友昭

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• 竹内 由和

  Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Takeuchi Yoshikazu

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• 森本 泰子

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 安川 秀仁

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 福森 義信

  神戸学院大学 薬学部

• Fukumori Yoshinobu

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 福田 友昭

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Morimoto Y

  Josai Univ. Saitama Jpn

• Morimoto Y

  Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology

• Morimoto Yasunori

  Fac. Of Pharmaceutical Sciences Josai Univ.

• Morimoto Yasunori

  Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Yasukawa Hidehito

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Morimoto Yasunori

  Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology

• Yamaoka Y

  Kobe‐gakuin Univ. Kobe Jpn

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