Antitumor Effects of a Novel Lipophilic Platinum Complex (SM-11355) against a Slowly-Groing Rat Hepatic Tumor after Intra-Hepatic Arterial Administration
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概要
- 論文の詳細を見る
The antitumor effects of cis[((1R, 2R)-1,2-cyclohexanediamine-N.N')bis(myristato)] platinum(II) (SM-11355)were evaluated in a rat hepatic tumor model, and were compared with those of cisplatin (CDDP). A novel slowlygrowing rat hepatic tumor model was established by the successive transplantation or rat AH109A Tumor into the ilver. The drugs, which were suspended in Lipiodol, were administered into the proper hepatic artery of tumor-bearing rats. Tumor growth was suppressed in the group that received SM-11355 suspended in Lipiodol(SM-11355/Lipiodol). Mean tumor growth rates in the groups administered 20 μl of Lipiodol containing 0,0.02,0.04,0.1,0.2,or 0.4 mg of SM-11355 were 244,86,110,81,51,and 40%, respectively. 1 week after treatiment. Those in the groups administered 20 μl of Lipiodol containing 0.1,0.2,or 0.4 mg of CDDP were 240,110,and 45%, respectively. In the groups administered 0.2 and 0.4 mg of SM-11355 or 0.4 mg of CDDP, massive necrosis was observed in the tumor tissue 1 week after drug administration, and the tumors disappeared 4 weeks after drug administration. Serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase(GPT) levels were measured as markers of liver damage one day after the drug was administered into the hepatic artery of rats. The minimum toxic dose, which raised serum GOT and GPT levels significantly compared with Lipiodol alone, was 0.2 mg for SM-11355/Lipiodol and 0.1 mg for CDDP/Lipiodol, respectively. The results demonstrated that SM-11355/Lipiodol exerted antitumor activity at a dose that showed no hepatic toxicity in the rat model, but CDDP/Lipiodol did not.
- 社団法人日本薬学会の論文
- 2000-03-01
著者
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竹内 洋文
50周年誌編集小委員会
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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Fukushima S
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
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Takeuchi Yoshikazu
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
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KISHIMOTO Shuichi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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TAKEUCHI Yoshikazu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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NOGUCHI Toshihiro
Sumitomo Pharmaceuticals Research Center
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YAMAMOTO Takashi
Sumitomo Pharmaceuticals Research Center
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竹内 義雄
富山大院医薬
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竹内 豊
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobegakuin University
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Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takeuchi Y
Faculty Of Pharmaceutical Sciences Okayama University
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Yamaoka Takashi
Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd
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Noguchi T
Sumitomo Pharmaceuticals Research Center
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Noguchi T
Research Center Sumitomo Pharmaceuticals Co. Ltd
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Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Yamaoka Takashi
Sumitomo Pharmaceutical Co. Ltd.
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Noguchi Takayuki
Department Of Anesthesiology Oita Medical University
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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