Lack of Inhibitory Effects of an Anti-angiogenesis Drug, TNP-470, on Rat Urinary Bladder Papillomatosis Induced by Mechanical Stimulation
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概要
- 論文の詳細を見る
The purpose of this study was to clarify whether the anti-angiogenesis drug TNP-470 may exert inhibitory effects on rat urinary bladder papillomatosis. A total of 46, six-week-old, male F344/DuCrj rats were used. In groups 1 and 2, 20 male F344/DuCrj rats each underwent intravesical instillation of 5 beads (1.5 mm diameter) via the abdomen to cause mechanical irritation. Group 3 was included as a control group without beads. Rats in group 1 were then treated with subcutaneous (s.c.) injections of TNP-470 at the dose of 30 mg/kg body wt, 3 times a week for 4 weeks. The vehicle alone was injected s.c. for groups 2 and 3. Subgroups of animals (10 rats each in groups 1 and 2, and 3 in group 3) were killed at weeks 2 and 4 after the beginning of the experiment. Urinary bladder weights of rats treated with intravesical instillation of beads (groups 1 and 2) were significantly increased compared with normal control rats (group 3). There was no difference between urinary bladder weights and calculi weights of groups 1 and 2 at 4 weeks. Histologically, the urinary bladder epithelium of rats suffering mechanical irritation due to the beads (groups 1 and 2) was significantly hyperplastic, demonstrating papillomatosis. There were no significant differences in the degrees or extents of epithelial lesions between groups 1 and 2. Furthermore, elevation of ODC and SAT activities, biomarkers of cell proliferation, in the epithelium was similar in both groups. TNP-470 thus did not inhibit epithelial proliferation in the urinary bladder in this experiment.
- 日本毒性病理学会の論文
- 2002-12-25
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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ICHIHARA Toshio
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Me
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Ichihara Toshio
Dims医科学研究所
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Ichihara Toshio
Department Of Pathology Osaka City University Medical School
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Ichihara T
Department Of Physics Graduate School Of Science Osaka University
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Ichihara Toshio
大阪市立大学 病理
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Wei Min
Department Of Pathology Osaka City University Medical School
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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MIN Wei
Department of Pathology, Osaka City University Medical School
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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OTANI Shuzo
Department of Second Biochemistry, Osaka City University Medical School
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YANO Yoshihisa
Department of Biochemistry, Osaka City University Medical School
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Ichihara Toshio
Department Of Physics Graduate School Of Science Osaka University
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Yano Y
Department Of Biochemistry Osaka City University Medical School
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Yano Yoshihisa
Department Of Biochemistry Osaka City University Graduate School Of Medicine
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Otani S
Department Of Biochemistry Osaka City University Medical School
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Otani Shuzo
Department Of Biochemistry Osaka City University Medical School
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Otani Shuzo
Department Of Biochemistry Osaka City University Graduate School Of Medicine
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Min Wei
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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ICHIHARA Toshio
Department of Earth and Space Science, Faculty of Science, Osaka University
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YANO Yoshihisa
Department of Advanced Energy, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan
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