Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N,N-dimethylformamide
スポンサーリンク
概要
- 論文の詳細を見る
Abnormal β-catenin protein accumulation in cytoplasm or nucleus with somatic mutation of β-catenin has been reported to be very frequent in hepatoblastomas (HBs) both in humans and in experimental animals. Recently we noted HBs developing in an evaluation of the carcinogenicity of N, N-dimethylformamide (DMF) in a 104 week mouse inhalation study1 performed by the Japan Bioassay Research Center. In the present study we evaluated β-catenin mutations in mouse HBs induced by DMF, which is considered to be a non-genotoxic carcinogen. Immunohistochemistry and polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analyses were performed using formalin-fixed and paraffin-embedded sections. No abnormal β-catenin accumulation or no apparent mutation was detected, and these findings point to functional normality of the Wnt signal pathway in these HBs induced by DMF. Our results raise questions as to the general nature of any relationship between HB and abnormal β-catenin accumulation.
- 日本毒性病理学会の論文
- 2004-12-30
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Kakizoe Tadao
Department Of Orthopaedic Surgery Osaka City University Medical School
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KAKUNI Masakazu
Department of Pathology, Osaka City University Medical School
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SENOH Hideki
Department of Pathology, Japan Bioassay Research Center
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TAKABA Katsumi
Department of Pathology, Osaka City University Medical School
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NAGANO Kasuke
Department of Pathology, Japan Bioassay Research Center
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Wanibuchi Hideki
大阪市立大学 核医
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Wanibuchi Hideki
Dept. Pathology Osaka City University Medical School
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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Senoh Hideki
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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長野 嘉介
Division Of Pathology Japan Bioassay Research Center
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Takaba Katsumi
Department Of Allergy Research Kyowa Hakko Kogyo Co. Ltd.
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KITANO Mitsuaki
Department of Pathology, Osaka City University Medical School
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Nagano K
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Nagano Kasuke
Department Of Pathology Japan Bioassay Research Center
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Senoh Hideki
Department Of Pathology Japan Bioassay Research Center
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Kakuni Masakazu
Department Of Pathology Osaka City University Medical School
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Kitano M
First Department Of Pathology Osaka City University Medical School
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Kitano Mitsuaki
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Japan Bioassay Research Center
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Senoh Hideki
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Kitano Mitsuaki
Takasago Research Laboratories Research Institute Kaneka Corporation
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長野 嘉介
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Takaba Katsumi
Department Of Pathology Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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