In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
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概要
- 論文の詳細を見る
SM-11355,cis[((1R, 2R)-1,2-cyclohexanediamine-N, N')bis(myristato)] platinum(II) is a lipophilic platinum complex. SM-11355 suspended in Lipiodol (SM-11355/Lipiodol) was previously shown to have antitumor effects against rat hepatic tumors after intra-arterial administration. In the present study, the in vitro release of platinum compounds from SM-11355/Lipiodol was examined. A test tube containing 10 ml of saline and 1 ml of SM-11355/Lipiodol was rotated at 5 rmp in a vertical orientation. The platinum concentration in saline gradually increased for 28 d. From HPLC analysis, cyclohexane-1,2-diamineplatinum(II) dichloride (DPC) and cyclohexane-1,2-diamineplatinum(II) chloroiodide (DPCI) were detected in the saline, and the sum of these two compounds was equivalent to the total platinum amount in the saline determined by atomic absorption spectrophotometry at days 21 and 28. DPC showed significant growth inhibitory activities, with IC_<50> values of 0.1-0.7 nmol/ml in rat hepatoma AH-109A cells and 5 human tumor cell lines, as effective as cisplatin. These findings suggest that SM-11355/Lipipdol exerts antitumor effects by releasing active platinum compounds, and that DPC is one of the candidates of the active compounds.
- 社団法人日本薬学会の論文
- 2000-05-01
著者
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竹内 洋文
50周年誌編集小委員会
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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Fukushima S
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
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Takeuchi Yoshikazu
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
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KISHIMOTO Shuichi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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TAKEUCHI Yoshikazu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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NOGUCHI Toshihiro
Sumitomo Pharmaceuticals Research Center
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YAMAOKA Takashi
Sumitomo Pharmaceuticals Research Center
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竹内 豊
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobegakuin University
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Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takeuchi Y
Faculty Of Pharmaceutical Sciences Okayama University
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Yamaoka Takashi
Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd
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Noguchi T
Sumitomo Pharmaceuticals Research Center
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Noguchi T
Research Center Sumitomo Pharmaceuticals Co. Ltd
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Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Yamaoka Takashi
Sumitomo Pharmaceutical Co. Ltd.
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Noguchi Takayuki
Department Of Anesthesiology Oita Medical University
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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