Stability of a 1β-Methylcarbapenem Antibiotic, Meropenem (SM-7338) in Aqueous Solution
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概要
- 論文の詳細を見る
The stability and the degradation products of 1β-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1β-methyl group against hydrolysis of β-lactam ring. As degradation products, the β-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of β-lactam ring by the amine of the second molecule were described.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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野口 哲男
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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竹内 豊
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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砂川 洵
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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五十部 穰
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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浜詰 ゆかり
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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濱詰 ゆかり
住友製薬総合研究所製剤技術研究所
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浜詰 ゆかり
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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竹内 豊
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Isobe Y
Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.
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砂川 洵
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Isobe Y
Japan Energy Corp. Saitama Jpn
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五十部 穣
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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