Synthetic Studies of Carbapenem and Penem Antibiotics. II. Synthesis of 3-Acetyl-2-azetidinones by (2+2) Cycloaddition of Diketene and Schiff Bases
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概要
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It was found that (2+2) cycloaddition reaction of diketene with Schiff bases was effectively promoted by imidazole as a catalyst to afford 3-acetyl-2-azetidinone derivatives 4. As an application of this new method, a practical asymmetric synthesis of 4 and its conversion into (3S, 4S)-4-carboxy-1-(di-p-anisylmethyl)-3-[(R)-1-hydroxyethyl]-2-azetidinone, which is a key intermediate for the synthesis of carbapenem and penem antibiotics, were accomplished.
- 公益社団法人日本薬学会の論文
- 1992-05-25
著者
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砂川 洵
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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佐々木 章
住友製薬(株)総合研究所
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砂川 洵
住友製薬総合研究所
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砂川 洵
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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佐々木 章
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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GODA Koshiro
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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榎本 正夫
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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榎本 正夫
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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