Synthetic Studies of Carbapenem and Penem Antibiotics. VI. Stereoselective Reduction of Enamino Ketone and Lactonization of the Reduction Product for the Synthesis of 1β-Methylcarbapenem
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概要
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The synthesis of the 1β-methylcarbapenem key intermediate 2 from the enamino ketone 6 was investigated. Stereoselective reduction of 6 and effective lactonization of the crude reduction product are described. The methyl group in 6 was shown to play an important role in these steps.
- 公益社団法人日本薬学会の論文
- 1994-12-15
著者
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砂川 洵
Research Center, Sumitomo Pharmaceuticals Co., Ltd.,
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砂川 洵
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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砂川 洵
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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松村 春記
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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野崎 義人
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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野崎 義人
Development Research Laboratories I Sumitomo Pharmaceuticals Research Center
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松村 春記
Development Research Laboratories I Sumitomo Pharmaceuticals Research Center
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- Synthetic Studies of Carbapenem and Penem Antibiotics. V. Efficient Synthesis of the 1β-Methylcarbapenem Skeleton
- Synthetic Studies of Carbapenem and Penem Antibiotics. IV. Stereoselective Reduction of 3-Acetyl-2-azetidinone with Aminoalkoxyborane
- Synthetic Studies of Carbapenem and Penem Antibiotics. III. A Synthesis of a Key Intermediate for 1β-Methylcarbapenem
- Synthetic Studies of Carbapenem and Penem Antibiotics. II. Synthesis of 3-Acetyl-2-azetidinones by (2+2) Cycloaddition of Diketene and Schiff Bases
- Synthetic Studies of Carbapenem and Penem Antibiotics. I. Facile Synthesis of a Key Intermediate : 4-Acetoxy-3-(1-hydroxyethyl)-2-azetidinone
- Dibenzotetracyclic Derivatives. II. Synthesis of 9-Aminoalkyl-9,10-dihydro-9,10-methanoanthracenes
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- Studies of Cyclodextrin Inclusion Complexes. II. Application of the Partition Coefficient Method
- Studies of Cyclodextrin Inclusion Complexes. I. Complex between Cyclodextrins and Bencyclane in Aqueous Solution
- Synthetic Studies of Carbapenem and Penem Antibiotics. VI. Stereoselective Reduction of Enamino Ketone and Lactonization of the Reduction Product for the Synthesis of 1β-Methylcarbapenem