Synthetic Studies of Carbapenem and Penem Antibiotics. V. Efficient Synthesis of the 1β-Methylcarbapenem Skeleton
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概要
- 論文の詳細を見る
An efficient synthesis of 1β-methylcarbapenem from the 1-(2-oxoazetidinyl)acetate 8 was developed by application of the Dieckmann reaction. Dieckmann-type cyclization of 8 and conversion to the enolphosphate 10 were achieved without epimerization to the 1α-methyl isomer in a one-pot procedure. Treatment with the mercaptan 22 after the phosphorylation resulted in a practical one-pot preparation of the 1β-methylcarbapenem derivative 23 from 8.
- 公益社団法人日本薬学会の論文
- 1994-07-15
著者
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佐々木 章
住友製薬(株)総合研究所
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砂川 洵
住友製薬総合研究所
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砂川 洵
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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佐々木 章
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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松村 春記
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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合田 公志郎
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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田本 克巳
Development Research Laboratories I, Sumitomo Pharmaceuticals Research Center
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田本 克己
Faculty Of Pharmaceutical Sciences University Of Tokyo
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田本 克巳
Development Research Laboratories I Sumitomo Pharmaceuticals Research Center
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合田 公志郎
Development Research Laboratories I Sumitomo Pharmaceuticals Research Center
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松村 春記
Development Research Laboratories I Sumitomo Pharmaceuticals Research Center
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- Synthetic Studies of Carbapenem and Penem Antibiotics. V. Efficient Synthesis of the 1β-Methylcarbapenem Skeleton
- Synthetic Studies of Carbapenem and Penem Antibiotics. IV. Stereoselective Reduction of 3-Acetyl-2-azetidinone with Aminoalkoxyborane
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