Inhibitory Activities of Novel Pyrimidine Derivatives on the Contact Hypersensitivity Reaction

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概要

• 論文の詳細を見る

• In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti-inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure-activity relationship (SAR) studies on the pyrimidine or the anti-oxidative moiety and the linker between them, the most potent compounds (10, 11) were obtained by the insertion of a C2 unit in compound 2c. The potencies of these compounds were 2-fold greater than that of 1. Compounds 10 and 11 were considered to be useful lead compounds having inexpensive anti-oxidative moieties without chirality.

• 公益社団法人日本薬学会の論文
• 2003-03-01

著者

• ISOBE Yoshiaki

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• TOBE Masanori

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• GOTO Yuso

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• INOUE Yoshifumi

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• OBARA Fumihiro

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• HAYASHI Hideya

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• Hayashi H

  Univ. Tokyo Tokyo Jpn

• Goto Y

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

• Tobe M

  Sumitomo Pharmaceuticals Co. Ltd. Osaka Jpn

• Obara Fumihiro

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• Hayashi H

  Drug Research Division Dainippon Sumitomo Pharma Co. Ltd.

• Hayashi Hideya

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• Hayashi H

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

• Hayashi Hideya

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

• Isobe Masakazu

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• Isobe Y

  Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.

• Isobe Yoshiaki

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• Isobe Y

  Sumitomo Pharmaceuticals Co. Ltd. Osaka Jpn

• Isobe Y

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• 五十部 穣

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Goto Yuso

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

• Tobe Masanori

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• Isobe Yoshiaki

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

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