Synthesis of Pyrimidine Derivatives Possessing an Antioxidative Property and Their Inhibitory Effects on Picryl Chloride-Induced Contact Hypersensitivity Reaction

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概要

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• We conducted a preliminary structure-activity relationship (SAR) study of some barbituric acid and uracil derivatives against the picryl chloride-induced contact hypersensitivity reaction. The introduction of an antioxidative moiety to the side chain of the C(6)-position of uracil was effective against this model. The introduction of dimethoxyphenol (8b) or dimethylphenol (8c) instead of di-t-butylphenol (8a) as an antioxidative moiety gave diminished activities, so, the reactive oxygen would contribute to the inflammation of this model, and an antioxidative activity was required for exhibiting the inhibitory activity. The inhibitory activity was significantly affected by the substituent at the N(1)-phenyl moiety.

• 公益社団法人日本薬学会の論文
• 2003-12-01

著者

• ISOBE Yoshiaki

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• Hirota Kosaku

  Laboratory Of Medicinal Chemistry Gifu Pharmaceutical University

• Isobe Yoshiaki

  Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation

• Hirota K

  Laboratory Of Medicinal Chemistry Gifu Pharmaceutical University

• Isobe Yoshiaki

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

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• Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of a Phenolic MPM Protective Group Using Pyridine as a Catalyst Poison

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