Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of a Phenolic MPM Protective Group Using Pyridine as a Catalyst Poison
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概要
- 論文の詳細を見る
Employment of a Pd/C-pyridine combination as a catalyst is a very useful method for the selective removal (hydrogenolysis) of phenolic O-benzyl, N-Cbz and benzyl ester protective groups and for the selective hydrogenation of nitro and olefin functions of phenol derivatives protected with the MPM group. These discriminatory results are apparently attributable to the effect of pyridine. The MPM group could be extensively applied to chemoselective hydrogenation as a protective group for phenolic hydroxyl functions.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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Hirota Kosaku
Laboratory Of Medicinal Chemistry Gifu Pharmaceutical University
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Sajiki H
Laboratory Of Medicinal Chemistry Gifu Pharmaceutical University
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Sajiki Hironao
Laboratories Of Medicinal Chemistry Gifu Pharmaceutical University
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Sajiki Hironao
Laboratories Of Medicinal Chemistry Gifu Pharmaceutical Univ.
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- Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of a Phenolic MPM Protective Group Using Pyridine as a Catalyst Poison
- Pd/C-catalyzed and Water-mediated Hiyama Cross-coupling Reaction Using an Electron-deficient Phosphine Ligand