Reactivities of 6-Amino-1,3-dimethyl-5-thioformyluracil toward Nucleophiles and Its Application to Synthesis of Pyrido[2,3-d]pyrimidines

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概要

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• The reaction of the 5-thioformyluracil 1 with phenylhydrazine and various amines readily afforded the hydrazone 3a and Schiff bases 3b-d, respectively. Further, carbanions and Wittig reagents reacted with 1 to give pyrido[2,3-d]pyrimidines 4 and 9. The corresponding 5-formyluracil 2 possessed much lower reactivities toward these nucleophiles than did 1.

• 公益社団法人日本薬学会の論文
• 1997-03-15

著者

• Hirota Kosaku

  Laboratory Of Medicinal Chemistry Gifu Pharmaceutical University

• KUBO Keiko

  Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University

• SAJIKI Hironao

  Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University

• Sajiki Hironao

  Laboratories Of Medicinal Chemistry Gifu Pharmaceutical University

• Sajiki Hironao

  Laboratories Of Medicinal Chemistry Gifu Pharmaceutical Univ.

関連論文

• Reactivities of 6-Amino-1,3-dimethyl-5-thioformyluracil toward Nucleophiles and Its Application to Synthesis of Pyrido[2,3-d]pyrimidines
• Pd/C(en) Catalyzed Chemoselective Hydrogenation in the Presence of Aryl Nitriles
• Efficient and Selective Pt/C-Catalyzed H-D Exchange Reaction of Aromatic Rings
• Synthesis of 6-Substituted 9-Benzyl-8-hydroxypurines with Potential Interferon-Inducing Activity
• Synthesis of Pyrimidine Derivatives Possessing an Antioxidative Property and Their Inhibitory Effects on Picryl Chloride-Induced Contact Hypersensitivity Reaction
• Pd/C-Catalyzed Chemoselective Hydrogenation in the Presence of a Phenolic MPM Protective Group Using Pyridine as a Catalyst Poison
• Pd/C-catalyzed and Water-mediated Hiyama Cross-coupling Reaction Using an Electron-deficient Phosphine Ligand

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