Synthesis of Potent and Selective Inhibitors against the Proliferation of Human Coronary Artery Smooth Muscle Cells
スポンサーリンク
概要
- 論文の詳細を見る
A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2h was much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of SMCs and the cell selectivity.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
-
ISOBE Yoshiaki
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
-
GOTO Yuso
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
-
HAYASHI Hideya
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
-
Hayashi H
Univ. Tokyo Tokyo Jpn
-
Goto Y
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
-
Hayashi H
Drug Research Division Dainippon Sumitomo Pharma Co. Ltd.
-
Hayashi Hideya
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
-
Hayashi H
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
-
Hayashi Hideya
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
-
Isobe Y
Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.
-
Isobe Yoshiaki
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
-
Isobe Y
Sumitomo Pharmaceuticals Co. Ltd. Osaka Jpn
-
TAKAKU Haruo
Drug Research Division, Dainippon Sumitomo Pharma Co., Ltd.
-
MISAWA Satoru
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
-
TAKAKU Haruo
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
-
OGITA Haruhisa
Research Division, Discovery Research Laboratories II, Sumitomo Pharmaceuticals Co. Ltd.
-
Isobe Y
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
-
五十部 穣
Research Center Sumitomo Pharmaceuticals Co. Ltd.
-
Goto Yuso
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
-
Takaku H
Drug Research Division Dainippon Sumitomo Pharma Co. Ltd.
-
Misawa Satoru
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
-
Misawa S
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
-
Ogita Haruhisa
Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.
-
OGITA Haruhisa
Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation
-
SEKINE Rena
Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation
-
Sekine Rena
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
-
Takaku Haruo
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
-
Isobe Yoshiaki
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
関連論文
- Stability of a 1β-Methylcarbapenem Antibiotic, Meropenem (SM-7338) in Aqueous Solution
- The Stability of a Novel Carbapenem Antibiotic, Meropenem (SM-7338), in a Solid State Formulation for Injection
- Localization of MT2a Gene Promoter Expression Is Different from the Site(s) of Copper Accumulation in the Roots of Transgenic Arabidopsis thaliana
- Synthesis and Activity of a Metabolite of (S)-6-Amino-5-(6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2, 4-(1H, 3H)-pyrimidinedione (CX-659S)
- Synthesis and Biological Evaluation of CX-659S and its Related Compounds for their Inhibitory Effects on the Delayed-Type Hypersensitivity Reaction.
- Possibility of companion cell-synthesized protein transport into Sieve Elements mitochondria
- ISOLATION AND CHARACTERIZATION OF THE BORl GENE
- DETECTION OF GREEN FLUORESCENCE PROTEIN AND β-GLUCURONIDASE PROTEIN IN THE PHLOEM SAP OF TRANSGENIC RICE PLANTS
- In Vitro Dissolution Tests Corresponding to the in Vivo Dissolution of Clarithromycin Tablets in the Stomach and Intestine
- A New Pharmacokinetic Model Including in Vivo Dissolution and Gastrointestinal Transit Parameters
- ANALYSIS OF COMPONENTS OF THE PLASTID PROTEIN IMPORT APPARATUS IN ARABIDOPSIS
- Study of Structure-Activity and Structure-Metabolism Relationships of HIV Protease Inhibitors
- The Combined Effect of Topical CX-659S, a Novel Diaminouracil Derivative, With Topical Corticosteroid on the Three Types of Allergic Responses in Mice or Guinea Pigs
- Selevtive Nonpeptidic Inhibitors of Herpes Simplex Virus Type 1 and Human Cytomegalovirus Proteases
- Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
- Prodrugs of 9-Benzyl-8-hydroxy-2- (2-hydroxyethylthio) adenine : Potent Interferon Inducing Agents in Monkeys
- Lanosterol Synthase in Dicotyledonous Plants
- Molecular Cloning and Characterization of Isomultiflorenol Synthse, a New Triterpene Synthase from Luffa cylindrica, Involved in Biosynthesis of Bryonolic Acid.
- Increases of Secondary Metabolite Production in Various Plant Cell Cultures by Co-cultivation with Cork.
- Increases of Secondary Metabolite Production in Various Plant Cell Cultures by Co-cultivation with Cork
- Synthesis and Evaluation of 6-Nitro-7-(1-piperazino) quinazolines: Dual-Acting Compounds with Inhibitory Activities toward Both Tumor Necrosis Factor-α (TNF-α) Production and T Cell Proliferation
- NITROGEN METABOLITE LEVELS REGULATETRANSCRIPTION OF RADISH GS1 GENE, Glin1;1 IN SUSPENSION-CULTUREDCELLS
- RNAs DETECTED IN THE RICE PHLOEM SAP
- Cell-to-cell movement of endogenous proteins in plants. : In the case of CPC protein and TRXh
- CDPK in rice phloem sap
- Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
- Field Survey of Glycyrrhiza Plants in Central Asia (3) Chemical Characterization of G. glabra Collected in Uzbekistan
- Field Survey of Glycyrrhiza Plants in Central Asia (2). : Characterization of Phenolics and Their Variation in the Leaves of Glycyrrhiza Plants Collected in Kazakhstan
- Field Survey of Glycyrrhiza Plants in Central Asia (1). Characterization of G. uralensis, G. glabra and the Putative Intermediate Collected in Kazakhstan
- ANALYSIS OF AUTOPHAGY IN HIGHER PLANTS
- ANALYSIS OF AUTOPHAGY IN HIGHER PLANTS
- RNAs IN THE RICE PHLOEM SAP : CONSTRUCTION AND SEQUENCE ANALYSIS OF cDNA LIBRARY FROM RICE PHLOEM SAP
- Cell-to-Cell movement of ToMV carrying a mutation in the movement protein in tobacco plants expressing rice thioredoxin h.
- Glutathione Levels in Phloem Sap of Rice Plants under Sulfur Deficient Conditions
- A New Method for Direct Introduction of Chemicals into a Single Sieve Tube of Intact Rice Plants
- ANALYSIS OF TRANSGENIC RICE EXPRESSING ANTISENSE RNA FOR CYTOSOLIC GLUTAMINE SYNTHETASE
- ANALYSIS OF GENES INVOLVED IN THE METABOLISM OF (NO)_2 IN ARABIDOPSIS THALIANA
- TRANSGENIC PLANT IN WHICH FLUORESCENCE INCREASE BY SULFUR DEFICIENCY
- TRANSLOCATION OF BORON FROM ROOTS TO SHOOTS IN AN Arabidopsis thaliana MUTANT, bor1-1
- Isolation and characterization of high-boron requiring mutants of Arabidopsis thaliana
- CHARACTERIZATION OF AN Arabidopsis SULFATE TRANSPORTER AST68 USING TRANSGENIC PLANTS
- A new method for direct introduction of chemicals into a single sieve tube of intact rice plants
- Preparation and Pharmacological Evaluation of Novel Glycoprotein (Gp) IIb/IIIa Antagonists. 2. Condensed Heterocyclic Derivatives
- Preparation and Pharmacological Evaluation of Novel Glycoprotein (Gp) IIb/IIIa Antagonists. 1. The Selection of Naphthalene Derivatives
- Synthesis and Evaluation of Novel 2-Oxo-1, 2-dihydro-3-quinolinecarboxamide Derivatives as Potent and Selective Serotonin 5-HT_4 Receptor Agonists
- Synthesis and Evaluation of Novel 2-Oxo-1,2-dihydro-3-quinolinecarboxamide Derivatives as Serotonin 5-HT_4 Receptor Agonists
- Inhibitory Activities of Novel Pyrimidine Derivatives on the Contact Hypersensitivity Reaction
- Synthesis of Potent and Selective Inhibitors against the Proliferation of Human Coronary Artery Smooth Muscle Cells
- Carboxyflavins, Novel Inhibitors of Taq DNA Polymerase.
- INVOLVEMENT OF A 13-KDA PROTEIN IN STABILIZATION OF OXYGEN EVOLUTION AGAINST HEAT INACTIVATION IN THE CYANOBACTERIUM, Synechococcus sp. PCC 7002
- THE HEAT TOLERANCE OF PHOTOSYNTHESIS INTHE CYANOBACTERIUM, Synechococcus PCC 7002 AND SOYBEAN CULTUREDCELLS
- Photosynthetic Adaptation to High Temperature Associated with Thylakoid Membranes of Synechococcus PCC7002
- Nitrate and Other Anions in the Rice Phloem Sap
- CATALYTIC DECOMPOSITION OF PHENOLIC RESIN ON RESINCOATED SAND MIXED WITH SEPIOLITE
- ADSORPTION OF AMMONIA BY SEPIOLITE IN AMBIENT AIR
- Identification of a Structure with Two Supereonducting Phases in L-Ba-Cu-O System (L=La or Y)
- Weak Flax-Pinning Effect between 230 K and 40 K in La_Sr_CuO_4
- FR901724,a Novel Anti-human Immunodeficiency Virus (HIV) Peptide Produced by Streptomyces, Shows Synergistic Antiviral Activities with HIV Protease Inhibitor and 2', 3'-Dideoxynucleosides
- Differential regulation of soyasaponin and betulinic acid production by yeast extract in cultured licorice cells
- Differential Expression of Three Oxidosqualene Cyclase mRNAs in Glycyrrhiza glabra(Pharmacognosy)
- Structure-Activity Relationships of 6-Nitroquinazolines : Dual-Acting Compounds with Inhibitory Activities toward both TNF-α Production and T Cell Proliferation
- The Effect of Cork Pieces on Pseudohypericin in Cells of Hypericum perforatum Shoots.
- Cloning and Characterization of a cDNA Encoding β-Amyrin Synthase Involved in Glycyrrhizin and Soyasaponin Biosyntheses in Licorice.
- Cloning and Characterization of a cDNA Encoding β-Amysin Synthase Involved in Glycyrrhizin and Soyasaponin Biosyntheses in Licorice
- Molecular Cloning and Characterization of a cDNA for Glycyrrhiza glabra Cycloartenol Synthase.
- Phylogenetic Relationship of Six Glycyrrhiza Species Based on rbcL Sequences and Chemical Constituents.
- Stimulation of the Production of Hypericins by Mannan in Hypericum perforatum Shoot Cultures.
- Phylogenetic Relationship of Six Glycyrrhiza Species Based on rbcL Sequences and Chemical Constituents
- Anticoagulant Peptides; Synthesis, Stability and Antithrombin Activity of Hirudin C-Terminal-Related Peptides and Their Disulfated Analog
- Antithrombotic Effects of Thrombin Anion-Binding Exosite Inhibitors
- Synthesis and Anticoagulant Activities of Disulfated Hirudin C-Terminal Related Peptides
- Practical Synthesis of Disulfated Hirudin C-Terminal Related Peptides
- Novel Syntheses of Murrayaquinone A and Furostifoline through 4-Oxygenated Carbazoles by Allene-Mediated Electrocyclic Reactions Starting from 2-Chloroindole-3-carbaldehyde
- Molecular Cloning and Characterization of a cDNA for Glycyrrhiza glabra Cycloartenol Synthase
- Anti-tumor Activity of Arginine Deiminase from Mycoplasma arginini and Its Growth-inhibitory Mechanism
- New Syntheses of Murrayaquinone A and Furostifoline
- Synthesis of Pyrimidine Derivatives Possessing an Antioxidative Property and Their Inhibitory Effects on Picryl Chloride-Induced Contact Hypersensitivity Reaction
- Improved Production of Phenomycin by a Genetically Engineered Escherichia coli
- Differential regulation of soyasaponin and betulinic acid production by yeast extract in cultured licorice cells
- Phylogenetic Relationship of Glycyrrhiza Plants Based on rbcL Sequences.
- Phylogenetic Relationship of Glycyrrhiza Plants Based on rbcL Sequences
- Most Clot-Bound Thrombin Activity is Inhibited by Plasma Antithrombin during Clot Aging, but a Very Small Fraction Survives
- Histone Deacetylase Inhibitors Up-regulate the Expression of Cell Surface MHC Class-I Molecules in B16/BL6 Cells
- Molecular Cloning and Characterization of Two cDNAs for Glycyrrhiza glabra Squalene Synthase.
- Molecular Cloning and Characterization of Two cDNAs for Glycyrrhiza glabra Squalene Synthase
- Seasonal Variation of Glycyrrhizin and Isoliquiritigenin Glycosides in the Root of Glycyrrhiza glabra L..
- Seasonal Variation of Glycyrrhizin and Isoliquiritigenin Glycosides in the Root of Glycyrrhiza glabra L.
- Organ specific localization of flavonoids in Glycyrrhiza glabra L..
- MOLECULAR CLONING AND FUNCTIONAL EXPRESSION OF cDNAs FOR GLYCYRRHIZA GLABRA SQUALENE SYNTHASE
- STUDIES ON INDEX COMPOUNDS FOR HPLC ANALYSIS OF GLYCYRRHIZA GLABRA