FR901724,a Novel Anti-human Immunodeficiency Virus (HIV) Peptide Produced by Streptomyces, Shows Synergistic Antiviral Activities with HIV Protease Inhibitor and 2', 3'-Dideoxynucleosides

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概要

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• A novel tricyclic 21-amino-acid peptide, FR901724,was isolated from the cultured broth of Streptomyces sp. No. 73264. This peptide appears to possess potent anti-human immunodeficiency virus (HIV) activity in vitro and might represent a lead to a new class of anti-HIV agents ; it qualifies as an HIV-cell fusion inhibitor because of its weak inhibition of virus-cell binding and strong inhibition of syncytium formation. From the time-of-addition experiments, the mode of action of FR901724 was found to definitely differ from that of KNI-272,a peptide mimetic allophenylnorstatine-derivative HIV protease inhibitor. FR901724 appears to interact with a stage of the virus replicative cycle that may well correspond to virus-cell fusion. We also found that FR901724 was synergistic or had a strong tendency toward synergism when combined with other antiviral drugs, such as KNI-272,AZT, ddI and dextran sulfate.

• 公益社団法人日本薬学会の論文
• 1996-03-15

著者

• ITO Masahiko

  Department of Physiology, Tokyo Women's Medical University School of Medicine

• HAYASHI Hideya

  Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation

• Hayashi Hideya

  Pharmaceutics And Biotechnology Laboratory Japan Energy Corporation

• Hayashi Hideya

  Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation

• Tsujii Eisaku

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Tsujii E

  Laboratory Of Antiviral Research Infectious Disease Research Exploratory Research Laboratories Fujis

• Nishihara Yutaka

  Fermentation Development Laboratories Fujisawa Pharmaceutical Co. Ltd.

• KINO Toru

  Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

• Kino Toru

  Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Ito Masahiko

  Department Of Microbiology Yamanashi Medical University

• Ito Masahiko

  Department Of Mathematics Nagoya University

• Ito Masahiko

  Department Of Integrated Biosciences Graduate School Of Frontier Sciences

• Ito Masahiko

  Department of Electrical Engineering and Electronics, Seikei University, 3-3-1 Kichijoji-Kitamachi, Musashino, Tokyo 180-8633, Japan

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