The Combined Effect of Topical CX-659S, a Novel Diaminouracil Derivative, With Topical Corticosteroid on the Three Types of Allergic Responses in Mice or Guinea Pigs
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概要
- 論文の詳細を見る
CX-659S ((S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4(1H,3H)-pyrimidinedione), a newly discovered anti-inflammatory compound, exerts inhibitory effects against picryl chloride-, oxazolone-, and dinitrochlorobenzene-induced acute contact hypersensitivity responses (CHRs) characterized by Th1-type reactions. Furthermore, this compound suppressed chronic CHRs characterized by Th2-type reactions, which is well known to mimic many, if not all, events occurring within the lesional skin of patients with atopic dermatitis (AD). The present study was conducted to determine the combined effect of topical CX-659S with topical corticosteroid on immediate type (ITR), late type (LTR), and delayed type hypersensitivity (DTHR) allergic reactions that are involved in AD. An ineffective dose of CX-659S (0.03 mg/ear) combined with betamethasone valerate (BV) significantly potentiated inhibitory activity of BV alone (0.1 μg/ear and 0.3 μg/ear) on both the ITR and the LTR in mice with the ovalbumin (OVA)-induced biphasic cutaneous reaction. Furthermore, the combined effect of CX-659S with BV was also observed on dinitrochlorobenzene (DNCB)-induced DTHR in guinea pigs. These results indicate that CX-659S has a combined effect with corticosteroids on every ITR, LTR, and DTHR. Proper treatment with corticosteroids for a safe and effective treatment of AD is needed. Thus, the combination therapy of topical CX-659S with topical corticosteroid would be one of the potential approaches for devising a proper treatment with corticosteroids.
- 社団法人 日本薬理学会の論文
- 2003-01-01
著者
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INOUE Yoshifumi
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
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HAYASHI Hideya
Pharmaceuticals and Biotechnology Laboratory, Japan Energy Corporation
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Hayashi H
Univ. Tokyo Tokyo Jpn
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Hayashi H
Drug Research Division Dainippon Sumitomo Pharma Co. Ltd.
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Hayashi Hideya
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
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Hayashi H
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
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Hayashi Hideya
Pharmaceuticals & Biotechnology Laboratory Japan Energy Corporation
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Isobe Masakazu
Pharmaceuticals And Biotechnology Laboratory Japan Energy Corporation
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Isobe Y
Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.
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Isobe Y
Sumitomo Pharmaceuticals Co. Ltd. Osaka Jpn
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Isobe Yoshiaki
Research Division Discovery Research Laboratories Ii Sumitomo Pharmaceuticals Co. Ltd.
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五十部 穣
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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