Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo[3,2-b]quinolines
スポンサーリンク
概要
- 論文の詳細を見る
Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
- 公益社団法人日本薬学会の論文
- 1997-02-15
著者
-
竹内 洋文
50周年誌編集小委員会
-
Takeuchi Yoshikazu
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
-
Yamato M
Okayama Univ. Science Okayama Jpn
-
Ono J
Faculty Of Pharmaceutical Sciences Okayama University
-
Yamato M
Faculty Of Science Okayama University Of Science
-
竹内 豊
Research Center Sumitomo Pharmaceuticals Co. Ltd.
-
TAKEUCHI Yasuo
Faculty of Pharmaceutical Sciences, Okayama University
-
Takeuchi Y
Faculty Of Pharmaceutical Sciences Okayama University
-
Oda Toshiaki
Faculty Of Pharmaceutical Sciences Okayama University
-
Yamaoka Takashi
Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd
-
Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
-
Ono Junko
Faculty Of Pharmaceutical Sciences Okayama University
-
Chang M‐r
Faculty Of Pharmaceutical Sciences Okayama University
-
Oda Y
Health Sci. Univ. Hokkaido Hokkaido Jpn
-
CHANG Ming-rong
Faculty of Pharmaceutical Sciences, Okayama University
-
OKAMOTO Yoko
Faculty of Pharmaceutical Sciences, Okayama University
-
ODA Yoko
Faculty of Pharmaceutical Sciences, Okayama University
-
HARADA Kyoko
Faculty of Pharmaceutical Sciences, Okayama University
-
HASHIGAKI Kuniko
Faculty of Pharmaceutical Sciences, Okayama University
-
YAMATO Masatoshi
Department of Science, Okayama University of Science
-
Harada Kyoko
Faculty Of Pharmaceutical Sciences Okayama University
-
Okamoto Yoko
Faculty Of Pharmaceutical Sciences Okayama University
-
Hashigaki K
Faculty Of Pharmaceutical Sciences Okayama University
-
Hashigaki Kuniko
Faculty Of Pharmaceutical Sciences Okayama University
-
Takeuchi Yasuo
Faculty Of Pharmaceutical Sciences Okayama University
-
Hashigaki Kuniko
Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center
関連論文
- Stability of a 1β-Methylcarbapenem Antibiotic, Meropenem (SM-7338) in Aqueous Solution
- The Stability of a Novel Carbapenem Antibiotic, Meropenem (SM-7338), in a Solid State Formulation for Injection
- Continuous Exposure to Low-Dose Cisplatin and Apoptosis(Miscellaneous)
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Transdermal Drug Delivery by Electroporation Applied on the Stratum Corneum of Rat Using Stamp-Type Electrode and Frog-Type Electrode in Vitro
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- Use of Electroporation to Accelerate the Skin Permeability Enhancing Action of Oleic Acid
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Petroselinic Acid and Oleic Acid : Comparison of Enhanced Skin Permeability Relative to Affinity for Saturated Fatty Acids of Stratum Corneum
- Antitumor Effects of a Novel Lipophilic Platinum Complex (SM-11355) against a Slowly-Groing Rat Hepatic Tumor after Intra-Hepatic Arterial Administration
- Asclepic Acid(cis-ω7-Octadecenoic Acid) as a Skin Penetration Enhancer : Its Behavior and Effects on Rat Stratum Corneum and Dermis
- Enhancement of Propylene Glycol Distribution in the Skin by High Purity cis-Unsaturated Fatty Acids with Different Alkyl Chain Lengths Haiving Different Double Bond Position
- Skin Penetration Enhancing Action of cis-Unsaturated Fatty Acids with ω-9,and ω-12-Chain Lengths
- Enhancement of Propylene Glycol Permeation into Rat Dermis Using High-purity Oleic Acid and Subsequent Alteration of the Dermal Protein Structures
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Effects of Fatty Acids, Fatty Amines and Propylene Glycol on Rat Stratum Corneum Lipids and Proteins in Vitro Measured by Fourier Transform Infrared/Attenuated Total Reflection (FT-IR/ATR) Spectroscopy
- Destabilization of Whole Skin Lipid Bio-liposomes Induced by Skin Penetration Enhancers and FT-IR/ATR (Fourier Transform Infrared/Attenuated Total Reflection) Analysis of Stratum Corneum Lipids
- Microgranulation and Encapsulation of Pulverized Pharmaceutical Powders with Ethyl Cellulose by the Wurster Process
- Effect of Additives on Physical Properties of Fine Ethyl Cellulose Microcapsules Prepared by the Wurster Process
- Coating of Pharmaceutical Powders by Fluidized Bed Process. IV. : Softening Temperature of Acrylic Copolymers and Its Relation to Film-Formation in Aqueous Coating
- Coating of Pharmaceutical Powders by Fluidized Bed Process. III. : Aqueous Coating with Ethyl Acrylate-Methyl Methacrylate-2-Hydroxyethyl Methacrylate Copolymer and the Dissolution Properties of the Products
- Coating of Pharmaceutical Powders by Fluidized Bed Process. II. : Microcapsules Produced by Layering of Fine Powder on Coarse Particles and Subsequent Aqueous Enteric Coating
- 粉体工学会の未来を考える
- 創立から25周年までの歩み
- A New Antitumor Agent Amrubicin Induces Cell Growth Inhibition by Stabilizing Topoisomerase II-DNA Complex
- Effect of +36T > C in intron 1 on the glutamine : fructose-6-phosphate amidotransferase 1 gene and its contribution to type 2 diabetes in different populations
- Concise Synthesis of dl-Febrifugine
- Re-revision of the Stereo Structure of Piperidine Lactone, an Intermediate in the Synthesis of Febrifugine
- Synthesis and Antimalarial Activity of Febrifugine Derivatives
- Reaction of N-Acylated Isofebrifugine with Acid
- In vitro Antitumor Activity, Intracellular Accumulation, and DNA Adduct Formation of cis-[((1R,2R)-1,2-Cyclohexanediamine-N,N')bis(myristato)] Platinum (II) Suspended in Lipiodol
- Coating of Pharmaceutical Powders by Fhiidized Bed Process. I. Aqueous Enteric Coating with Methacrylic Acid-Ethylacrylate Copolymer and the Dissolution Behavior of Products(Pharmaceutical)
- Physical Characterization of Erythromycin Dihydrate, Anhydrate and Amorphous Solid and Their Dissolution Properties
- 細粒と粉末の混合に関する研究(第2報)細粒と微粉砕粉末の混合状態
- 細粒と粉末の混合--混合性におよぼす粉末粒子径と付着力の効果 (〔粉体工学会〕夏期シンポジウム特集)
- SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population
- No evidence for association of the ENPP1 (PC-1) K121Q variant with risk of type 2 diabetes in a Japanese population
- MITOGENIC ACTIVITY AND IN VITRO FERTILIZATION INHIBITORY ACTIVITY OF GENYPTERUS BLACODES LECTIN
- PURIFICATION AND CHARACTERIZATION OF A FISH LECTIN FROM THE EXTERNAL MUCOUS OF OPHIDIIDAE, GENYPTERUS BLACODES
- Synthesis of Acinetobactin
- Infrequent Detectable Somatic Mutations of the RET and Glial Cell Line-derived Neurotrophic Factor (GDNF) Genes in Human Pituitary Adenomas
- Aryl-Aryl Coupling Reaction Using a Novel and Highly Active Palladium Reagent Prepared from Pd(OAc)_2, 1,3-Bis [diphenylphosphino] propane (DPPP), and Bu_3P
- One-Pot Conversion of Allyl Alcohols into Selenochroman Derivatives
- Synthesis of Arnottin I through a Palladium-Mediated Aryl-Aryl Coupling Reaction
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. V. Methylindolo[3,2-b]quinolines
- Synthese and Antifungal Activity of dl-Griseofulvin and Its Congeners. III
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo[3,2-b]quinolines
- Syntheses and Antifungal Activity of dl-Griseofulvin and Its Congeners. II
- MOLECULAR MODIFICATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF ANTITUMOR ACTIVE INDOLOQUINOLINE DERIVATIVES
- Intramolecular Michael Reaction in Diastereoselective Synthesis of dl-Griseofulvin
- STUDY ON STRUCTURE-ACTIVITY RELATIONSHIP USING MOLECULAR ORBITAL METHOD (PM3)
- SYNTHESIS AND ANTITUMOR ACTIVITY OF FUSED TETRACYCLIC QUINOLINE DERIVATIVES
- Synthesis and Structure-Activity Relationships of Antitumor-active Tropolone Derivatives
- The Rate of Cell Growth Is Regulated by Purine Biosynthesis via ATP Production and G1 to S Phase Transition
- The Diels-Alder Reaction Using a Vinyl Sulfoxide Activated by the Participation of a Neighboring Epoxide Group
- Synthesis and Siderophore Activity of Vibrioferrin and One of Its Diastereomeric Isomers
- Total Synthesis of dl-Febrifugine and dl-Isoferifugine
- Total Synthesis of the Siderophore Vibrioferrin
- REACTION OF ETHYL β-ALKYLAMINOCROTONATES IN THE PRESENCE OF ORGANIC ACID
- EXPERIMENTAL ANALYSIS OF ANOMALOUS DISPOSITIONS IN DISEASE STATES : DRUG PHARMACOKINETICS IN RATS WITH HEPATIC DISEASES
- Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of human hepatoma cells orthotopically implanted in nude rats
- Amrubicin, a novel 9-aminoanthracycline, enhances the antitumor activity of chemotherapeutic agents against human cancer cells in vitro and in vivo
- Amrubicin induces apoptosis in human tumor cells mediated by the activation of caspase-3/7 preceding a loss of mitochondrial membrane potential
- Uptake and Intracellular Distribution of Amrubicin, a Novel 9-Amino-anthracycline, and Its Active Metabolite Amrubicinol in P388 Murine Leukemia Cells
- Cytotoxicity of Amrubicin, a Novel 9-Aminoanthracycline, and Its Active Metabolite Amrubicinol on Human Tumor Cells
- Tumor-selective Distribution of an Active Metabolite of the 9-Aminoanthracycline Amrubicin
- In vivo Efficacy and Tumor-selective Metabolism of Amrubicin to Its Active Metabolite
- Expression of somatostatin receptor subtypes and growth inhibition in human exocrine pancreatic cancers
- ASYMMETRIC SYNTHESES OF TETRAHYDROISOQUINOLINE AND TETRAHYDRO-β-CARBOLINE DERIVATIVES