Coating of Pharmaceutical Powders by Fluidized Bed Process. IV. : Softening Temperature of Acrylic Copolymers and Its Relation to Film-Formation in Aqueous Coating
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概要
- 論文の詳細を見る
The softening temperature (T_s) of films of commercially available and newly developed acrylic copolymers for aqueous coating was measured by thermomechanical analysis. The results are discussed in relation to the film-formation of their latices in the Wurster process.Methacrylic acid (MA)-ethyl acrylate (EA) (1 : 1) copolymer dispersion (Eudragit L30D-55) containing 10% triacetin exhibited excellent film-forming ability in coating at a temperature (31℃) for lower than its T_s (91℃). The product exhibited no stickiness during drying at 60℃. The dissolution properties were little changed by heating at 60℃.On the other hand, the copolymer dispersion consisting of hydrophobic acylic esters and minor quatenary ammonium esters (Eudragit RS30D, T_s=83℃) did not form a film under the same coating conditions in spite of its T_s being lowered to 49℃ by the addition of 10% triacetin. The product was sticky during drying at 60℃. The copolymer consisting of only hydrophobic esters (Eudragit E30D) had a good film-forming ability due to its low T_s (18℃), but hte product was too sticky to be discrete particles even at room temperature.With the aqueous dispersion of EA-methyl methacrylate (MMA)-2-hydroxyethyl methacrylate (HEMA) copolymer, newly developed in the previous study, the hydrophilic HEMA enhanced the film-formation. In particular, the EA-MMA-HEMA (6 : 12 : 8) copolymer exhibited excellent film-formation in spite of its high T_s (78℃), and the prolonged release characteristic of the product was not changed by heating it at 60℃.These results suggested that hydrophilic residues such as carboxyl and hydroxyl contribute to film-formation of the latices.
- 社団法人日本薬学会の論文
- 1988-12-25
著者
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竹内 由和
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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山岡 由美子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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福田 友昭
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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福森 義信
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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市川 秀喜
神戸学院大学薬学部
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市川 秀喜
神戸学院大学薬学部物性薬学部門製剤学研究室 同ライフサイエンス産学連携研究センター
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竹内 由和
神戸学院大学薬学部臨床薬学部門薬剤学研究室
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山岡 由美子
Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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市川 秀喜
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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大迫 義文
Fuji Paudal
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竹内 由和
Department Of Parmaceutics Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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福森 義信
神戸学院大学 薬学部
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福田 友昭
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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竹内 由和
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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山岡 由美子
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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大迫 義文
不二パウダル(株)開発部
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市川 秀喜
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin University
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