In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
スポンサーリンク
概要
- 論文の詳細を見る
SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II), is a lipophilic platinum complex.SM-11355 suspended in Lipiodol (SM-11355/Lipiodol) was shown to have antitumor activity against hepatic tumors after intra-hepatic arterial administration in animal models. In this study, the in vitro growth inhibitory activities of SM-11355 and ciSplatin (CDDP) following 7-d drug exposure were examined using rat ascite hepatoma AH-109A cells and various human tumor cell lines. In monolayer or suSpension cell cultures, SM-11355 did not inhibit the cell growth, whereas SM-11355/Lipiodol had dose-dependent growth inhibitory activities, as did CDDP suspended in Lipiodol (CdDP/Lipiodol). This was also the case in the colony formation assay in agarose gel. CDDP/Lipiodol released platinum compound into the culture medium rapidly, whereas SM-11355/Lipiodol released it slowly but constantly for 7 d. Furthermore, a significant amount of platinum was detected in the cells treated with CDDP/Lipiodol and SM-11355/Lipiodol. These results suggest that Lipiodol plays an important role in the in vitro cytotoxicity of SM-11355,and certain platinum compounds released from SM-11355/Lipiodol have growth inhibitory effects on these cells.
- 社団法人日本薬学会の論文
- 2000-04-01
著者
-
竹内 洋文
50周年誌編集小委員会
-
FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
-
Fukushima S
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
-
Takeuchi Yoshikazu
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
-
KISHIMOTO Shuichi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
TAKEUCHI Yoshikazu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
NOGUCHI Toshihiro
Sumitomo Pharmaceuticals Research Center
-
YAMAOKA Takashi
Sumitomo Pharmaceuticals Research Center
-
竹内 豊
Research Center Sumitomo Pharmaceuticals Co. Ltd.
-
Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobegakuin University
-
Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Takeuchi Y
Faculty Of Pharmaceutical Sciences Okayama University
-
Yamaoka Takashi
Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd
-
Noguchi T
Sumitomo Pharmaceuticals Research Center
-
Noguchi T
Research Center Sumitomo Pharmaceuticals Co. Ltd
-
Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
-
Yamaoka Takashi
Sumitomo Pharmaceutical Co. Ltd.
-
Noguchi Takayuki
Department Of Anesthesiology Oita Medical University
-
Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
関連論文
- Stability of a 1β-Methylcarbapenem Antibiotic, Meropenem (SM-7338) in Aqueous Solution
- The Stability of a Novel Carbapenem Antibiotic, Meropenem (SM-7338), in a Solid State Formulation for Injection
- Quantitative Determination of Ergothioneine in Plasma and Tissues by TLC-Densitometry
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- 01P2-143 血中エフェドリン濃度を指標とした葛根湯エキス製剤投与スケジュールの改善
- Continuous Exposure to Low-Dose Cisplatin and Apoptosis(Miscellaneous)
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Transdermal Drug Delivery by Electroporation Applied on the Stratum Corneum of Rat Using Stamp-Type Electrode and Frog-Type Electrode in Vitro
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- Use of Electroporation to Accelerate the Skin Permeability Enhancing Action of Oleic Acid
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Petroselinic Acid and Oleic Acid : Comparison of Enhanced Skin Permeability Relative to Affinity for Saturated Fatty Acids of Stratum Corneum
- Antitumor Effects of a Novel Lipophilic Platinum Complex (SM-11355) against a Slowly-Groing Rat Hepatic Tumor after Intra-Hepatic Arterial Administration
- Asclepic Acid(cis-ω7-Octadecenoic Acid) as a Skin Penetration Enhancer : Its Behavior and Effects on Rat Stratum Corneum and Dermis
- Enhancement of Propylene Glycol Distribution in the Skin by High Purity cis-Unsaturated Fatty Acids with Different Alkyl Chain Lengths Haiving Different Double Bond Position
- Skin Penetration Enhancing Action of cis-Unsaturated Fatty Acids with ω-9,and ω-12-Chain Lengths
- Enhancement of Propylene Glycol Permeation into Rat Dermis Using High-purity Oleic Acid and Subsequent Alteration of the Dermal Protein Structures
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N,N-dimethylformamide
- Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice
- Lack of Inhibition of BBN-induced Bladder Carcinogenesis in C57BL/6 Mice by Intravesical Instillation of KRN 7000
- P6-02 Enhancement of thioacetamide-induced liver cirrhosis by estradiol 3-benzoate in the rats(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Carcinogenicity of Dimethylarsinic Acid in F344 Rats and p53 (+/-) Knockout and Wild Type C57BL/6J Mice. Relevance with Genetic Alterations and Oxidative DNA Damage (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual
- Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis
- Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats
- Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity
- Effects of Fatty Acids, Fatty Amines and Propylene Glycol on Rat Stratum Corneum Lipids and Proteins in Vitro Measured by Fourier Transform Infrared/Attenuated Total Reflection (FT-IR/ATR) Spectroscopy
- Destabilization of Whole Skin Lipid Bio-liposomes Induced by Skin Penetration Enhancers and FT-IR/ATR (Fourier Transform Infrared/Attenuated Total Reflection) Analysis of Stratum Corneum Lipids
- Microgranulation and Encapsulation of Pulverized Pharmaceutical Powders with Ethyl Cellulose by the Wurster Process
- Effect of Additives on Physical Properties of Fine Ethyl Cellulose Microcapsules Prepared by the Wurster Process
- Coating of Pharmaceutical Powders by Fluidized Bed Process. IV. : Softening Temperature of Acrylic Copolymers and Its Relation to Film-Formation in Aqueous Coating
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Histological and Mucin Histochemical Study of Colon Ulcers Induced in Rats by a Rapid Freezing Method
- 粉体工学会の未来を考える
- 創立から25周年までの歩み
- Di-n-butyl Phthalate is Toxic to the Male Reproductive System and Its Toxicity is Enhanced by Thioacetamide Induced Liver Injury
- Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse
- Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) in rats
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- Sequence Analysis of Genes Encoding Rodent Homologues of the Human Tumor-rejection Antigen SART-1
- p53 and H-ras Mutations and Microsatellite Instability in Renal Pelvic Carcinomas of NON/Shi Mice Treated with N-Butyl-N-(4-hydroxybutyl)-nitrosamine: Different Genetic Alteration from Urinary Bladder Carcinoma
- p53 in Multiple Human Urothelial Cancers: Assessment for Clonality by the Yeast p53 Functional Assay in Combination with p53 Immunohistochemistry
- Loss of Heterozygosity in (Lewis×F344)F_1 Rat Urinary Bladder Tumors Induced with N-Butyl-N-(4-hydroxybutyl) nitrosamine Followed by Dimethylarsinic Acid or Sodium L-Ascorbate
- Susceptibility of Four F_1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis
- Pharmacokinetics of Ephedrine and Pseudoephedrine after Oral Administration of Kakkonto to Healthy Male Volunteers
- Chemopreventive Effects of Bovine Lactoferrin on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Rat Bladder Carcinogenesis
- In vitro Antitumor Activity, Intracellular Accumulation, and DNA Adduct Formation of cis-[((1R,2R)-1,2-Cyclohexanediamine-N,N')bis(myristato)] Platinum (II) Suspended in Lipiodol
- Physical Characterization of Erythromycin Dihydrate, Anhydrate and Amorphous Solid and Their Dissolution Properties
- 細粒と粉末の混合に関する研究(第2報)細粒と微粉砕粉末の混合状態
- 細粒と粉末の混合--混合性におよぼす粉末粒子径と付着力の効果 (〔粉体工学会〕夏期シンポジウム特集)
- Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker
- Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident
- Hormesis in Carcinogenicity of Non-genotoxic Carcinogens
- Aberrant expression of E-cadherin and β-catenin in association with transforming growth factor-β1 in urinary bladder lesions in humans after the Chernobyl accident
- Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol : Evidence for a threshold
- Examination of the Rat Model of Liver Injury via Thioacetamide (TAA) or Carbon Tetrachloride (CCl_4)
- Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxybutyl)-nitrosamine
- Biphasic Increase of Epithelial DNA Synthesis in the Urinary Bladder of Rats Treated with a Tumor Promoter, Sodium L-ascorbate
- Experimental Study of the Relationship between Perfluoro-Octyl Bromide Emulsion and Norepinephrine Release in Reperfusion Arrhythmia : Isolated Guinea Pig Heart Model
- Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation
- Lack of Inhibitory Effects of an Anti-angiogenesis Drug, TNP-470, on Rat Urinary Bladder Papillomatosis Induced by Mechanical Stimulation
- Modulation of the Pharmacokinetics of 5'-Deoxy-5-fluorouridine and 5-Fluorouracil in Rats by Oral Co-administration of Acyclothymidine
- Anticancer Activity of Free γ-Linolenic Acid on AH-109A Rat Hepatoma Cells and the Effect of Serum Albumin on Anticancer Activity of γ-Linolenic Acid in Vitro
- Hydrolysis of 3', 5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in Rabbit and Human Plasma and Its Release from Oily Solution
- Lack of Inhibitory Effects of Coumaperine from Pepper on the Promotion Stage of Chemical Hepatocarcinogenesis in the Rat
- Isolation of Differentiated Squamous and Undifferentiated Spindle Carcinoma Cell Lines with Differing Metastatic Potential from a 4-Nitroquinoline N-Oxide-induced Tongue Carcinoma in a F344 Rat
- Inhibitory effect of phenobarbital at low dose on rat hepatocarcinogenesis : the evidence for hormesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Thresholds for Carcinogenicity of Environmental Carcinogens (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- Application of liquid chromatography-tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally
- Lack of Enhanced Epithelial Cell Proliferation in the Urinary Bladder of Heterozygous p53 Knockout Mice Given Sodium Ortho-phenylphenate or Uracil
- Are tobacco use and urine pH indicated as risk factors for bladder carcinoma?
- PREPARATION AND EVALUATION OF W/O TYPE AND W/O/W TYPE EMULSIONS CONTAINING AN ANTICANCER DRUG
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. V. Methylindolo[3,2-b]quinolines
- Synthese and Antifungal Activity of dl-Griseofulvin and Its Congeners. III
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo[3,2-b]quinolines
- Syntheses and Antifungal Activity of dl-Griseofulvin and Its Congeners. II
- MOLECULAR MODIFICATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF ANTITUMOR ACTIVE INDOLOQUINOLINE DERIVATIVES
- Intramolecular Michael Reaction in Diastereoselective Synthesis of dl-Griseofulvin
- STUDY ON STRUCTURE-ACTIVITY RELATIONSHIP USING MOLECULAR ORBITAL METHOD (PM3)
- SYNTHESIS AND ANTITUMOR ACTIVITY OF FUSED TETRACYCLIC QUINOLINE DERIVATIVES
- S4-5 Analysis of Arsenic Carcinogenicity : Using Animal Models(SYMPOSIUM 4: ARSENIC IN THE ENVIRONMENT AND THE TOXICITY)(Proceedings of the 31st Annual Meeting)
- Experimental Studies on Artificial Blood Usage for Hemodilution during Cardiopulmonary Bypass
- Total Synthesis of the Siderophore Vibrioferrin
- Preparation of and Drug Release from W/O/W Type Double Emulsions Containing Anticancer Agents Using an Oily Lymphographic Agent as an Oil Phase(Pharmaceutical)