Lack of Inhibitory Effects of Coumaperine from Pepper on the Promotion Stage of Chemical Hepatocarcinogenesis in the Rat
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概要
- 論文の詳細を見る
We previously indicated that coumaperine isolated from pepper can protect against the initiation of rat hepatocarcinogenesis. In the present study, potential modifying effects of coumaperine on post-initiation promotion stage were examined, using a medium term rat liver bioassay (Ito test). F344 rats were given a single intraperitoneal injection of diethylnitrosamine (200 mg/kg body wt.) and subjected to two-thirds partial hepatectomy at week 3. Commencing 2 weeks from the start, coumaperine at doses of 0, 2, 10, 50 mg/kg body wt. was given to the rats for 6 weeks. All surviving animals were killed at week 8, and their livers were immunohistochemically examined for expression of glutathione S-transferase placental form (GST-P) and transforming growth factor-α (TGF-α). The numbers and areas of GST-P positive foci in rats given 2, 10 or 50 mg/kg coumaperine were comparable to the control values. There were also no significant intergroup differences regarding numbers and areas of TGF-α positive foci. This study suggested that coumaperine does not inhibit liver carcinogenesis in the promotion stage.
- 日本毒性病理学会の論文
- 2003-09-30
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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KITANO Mitsuaki
First Department of Pathology, Osaka City University Medical School
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KIKUZAKI Hiroe
Laboratory of Food Chemistry, Department of Food and Nutrition Faculty of Science of Living, Osaka C
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NAKATANI Nobuji
Laboratory of Food Chemistry, Department of Food and Nutrition Faculty of Science of Living, Osaka C
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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WADA Jutaro
Pharmacology and Toxicology Group, Life Science Research Laboratories, Life Science RD Center, Kanek
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ARIKI Yutaka
Pharmacology and Toxicology Group, Life Science Research Laboratories, Life Science RD Center, Kanek
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HIDAKA Takayoshi
Pharmacology and Toxicology Group, Life Science Research Laboratories, Life Science RD Center, Kanek
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KITANO Mitsuaki
Department of Pathology, Osaka City University Medical School
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Hidaka Takayoshi
Pharmacology And Toxicology Group Life Science Research Laboratories Life Science Rd Center Kaneka C
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Kitano M
First Department Of Pathology Osaka City University Medical School
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Kitano Mitsuaki
Department Of Pathology Osaka City University Medical School
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TANABE Yoo
Department of Chemistry, School of Science and Technology, Kwansei Gakuin University
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Tanabe Yoo
Department Of Chemistry School Of Science And Technology Kwansei Gakuin University
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Wada Jutaro
Pharmacology And Toxicology Group Life Science Research Laboratories Life Science Rd Center Kaneka C
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Ariki Yutaka
Pharmacology And Toxicology Group Life Science Research Laboratories Life Science Rd Center Kaneka C
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Kikuzaki H
Osaka City Univ. Osaka Jpn
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Nakatani N
Osaka City Univ. Osaka Jpn
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Nakatani Nobuji
Laboratory Of Food Chemistry Faculty Of Science Of Living Osaka City University
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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