Examination of the Rat Model of Liver Injury via Thioacetamide (TAA) or Carbon Tetrachloride (CCl_4)
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概要
- 論文の詳細を見る
In the present study, a suitable rat model for testing the modifying effect of liver injury on the rat male organ toxicity of endocrine disrupters was researched using thioacetamide (TAA) and carbon tetrachloride (CCl4) as liver toxicants. Male 8-week-old F344 rats were divided into six groups as follows. Animals in groups 1 and 2 were given 200 and 100 mg/kg body weight of TAA with PBS by intraperitoneal injection (ip.) 3 times a week for 4 weeks, respectively. Group 3 was given PBS only. Animals in groups 4 and 5 were given 2 and 1 mg/kg body weight of CCl4 with corn oil by subcutaneous injection (sc.) once a week, for 4 weeks, respectively. Group 6 was given corn oil only. Three rats from each group were sacrificed at week 4 and the rest of groups 1 and 4 were sacrificed after a further 4 weeks of withdrawal period. In the animals administered 200 mg/kg of TAA the findings of apparent liver damage on both histopathological and biochemistrical examinations could be seen: fibrosis, enlargement of Glissons sheath and infiltration of inflammatory cells in the liver, and apparent elevation of serum aspartate aminotransferase and alanine aminotransferase levels. On the other hand, in the animals administered 2 mg/kg of CCl4 only the histopathological findings of liver damages could be seen: fatty and inflammatory changes in liver. In the animals administered 100 mg/kg of TAA or 1 mg/kg body weight of CCl4 only the histopathological findings of slight inflammatory changes in their liver samples. However these findings of liver damage were almost completely absent after the 4-week withdrawal period.
- 日本毒性病理学会の論文
- 2004-09-30
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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Nakatani Tatsuya
Department of Urology, Osaka City University Medical School
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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MITSUHASHI Makoto
Department of Pathology, Osaka City University Medical School
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WADA Seiji
Department of Urology, Osaka City University Medical School
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Mitsuhashi Makoto
Department Of Pathology Osaka City University Medical School
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Nakatani T
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
大阪市立大学 医学部臓器器官病態外科学
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Nakatani Tatsuya
大阪市立大学 医研究臓器器官病態外
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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Wada Seiji
Department Of Urology Osaka City University Medical School
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Wada Seiji
大阪市立大学 医学部病理学
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KIYOTA Atsuhiko
Department of Urology, Osaka City University Medical School
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Kiyota Atsuhiko
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Biochemistry Kinki University School Of Medicine
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Kiyota Atsuhiko
Department Of Pathology Osaka City University Medical School
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Wada Seiji
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Nakatani Tatsuya
Departments Of Pathology And Urology Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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