Lack of Inhibition of BBN-induced Bladder Carcinogenesis in C57BL/6 Mice by Intravesical Instillation of KRN 7000
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概要
- 論文の詳細を見る
The immunostimulatory α-galactosylceramide, KRN 7000 or (2S, 3S, 4R)-1-0-(α-D-galactopyranosyl)-2-(N-hexacosnoylamino)-1,3,4-octadecatrienol, might be anticipated to have antitumor activity in vivo apart from any direct toxicity to cancer cells. We investigated inhibition of mouse bladder carcinogenesis by intravesically instillated KRN 7000. C57BL/6 mice were divided into 4 groups; all first receiving the carcinogen 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in drinking water for 8 weeks. Next, groups 1 and 2, respectively were administered 10 and 0.1 μg/kg of KRN 7000 intravesically once weekly for 17 weeks. Group 3 received only 0.3 ml of saline (vehicle control). Group 4 did not undergo bladder catheterization. By histologic examination at 26 weeks, the incidence of bladder carcinoma of all types tended to be higher in group 1 than in group 3, but without significance. The incidence of bladder carcinoma in group 4, (no catheterization), was similar to that in group 1. Only one precancerous lesion (papillary or nodular dysplasia) was seen in each of groups 3 and 4. Thus vesical instillation of KRN 7000 did not inhibit bladder carcinogenesis in mice, exposed to the carcinogen studied.
- 日本毒性病理学会の論文
- 2003-03-30
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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WEI Min
Department of Pathology, Osaka City University Medical School
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Nakatani Tatsuya
Department of Urology, Osaka City University Medical School
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KAKIZOE Tadao
National Cancer Center Hospital
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Kakizoe Tadao
Department Of Orthopaedic Surgery Osaka City University Medical School
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MITSUHASHI Makoto
Department of Pathology, Osaka City University Medical School
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MASUDA Chikayoshi
Department of Urology, Osaka City University Medical School
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WADA Seiji
Department of Urology, Osaka City University Medical School
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Masuda Chikayoshi
Department Of Urology Osaka City University Medical School
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Mitsuhashi Makoto
Department Of Pathology Osaka City University Medical School
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Nakatani T
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
大阪市立大学 医学部臓器器官病態外科学
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Nakatani Tatsuya
大阪市立大学 医研究臓器器官病態外
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Wei Min
Department Of Pathology Osaka City University Medical School
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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Wada Seiji
Department Of Urology Osaka City University Medical School
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Wada Seiji
大阪市立大学 医学部病理学
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Kakizoe Tadao
National Cancer Center
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Urology Osaka City University Medical School
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Nakatani Tatsuya
Department Of Biochemistry Kinki University School Of Medicine
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Wei Min
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Wada Seiji
Department Of Obstetrics And Gynecology The Jikei University School Of Medicine
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Nakatani Tatsuya
Departments Of Pathology And Urology Osaka City University Medical School
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Takaba Katsumi
Department Of Pathology Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Min Wei
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Doi Ken'ichiro
Departments Of Pathology And Urology Osaka City University Medical School
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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