Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice
スポンサーリンク
概要
- 論文の詳細を見る
The carcinogenic potential of long term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was investigated in severe combined immunodeficiency (SCID) mice. A total of 130 female SCID mice, 7 weeks old, were administered 0 (45 mice) or 300 ppm IQ (85 mice) in the diet for 78 weeks. IQ-treatment and control groups were sacrificed at weeks 32, 52, and 78, and examined for tumorigenicity in the colon and other organs. The survival rate was 46% (control group) and 50% (IQ-treatment group) at the termination of the experiment 78 weeks. Tumors in the liver were significantly increased in the 300 ppm-IQ treated mice. Concerning colon cancer development, aberrant crypt foci (ACF), putative pre-cancerous lesions of the colon, were found in all IQ-treated mice at 32, 52, and 78 weeks. The number of ACF was increased in relation to the duration of exposure. The major induction site of ACF was the proximal colon, however, no colon tumors were observed except for an inflammatory polyp. One of the intestinal microflora, Lactobacillus, which was reported to detoxify IQ, was detected in IQ-treated and non-treated mice. Thus IQ showed hepatocarcinogenicity in SCID mice of the present study, but not colon carcinogenicity.
- 日本毒性病理学会の論文
- 2004-03-30
著者
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HOSHI Manabu
Department of Orthopedic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Researc
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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WANIBUCHI Hideki
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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NOMURA Taisei
Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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TAKAOKA Kunio
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine
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Kakizoe Tadao
Department Of Orthopaedic Surgery Osaka City University Medical School
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SALIM Elsayed
Department of Pathology, Osaka City University Medical School
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MURAI Takashi
Department of Pathology, Osaka City University Medical School
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Salim E
Department Of Pathology Osaka City University Medical School
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Salim Elsayed
大阪市立大学 医学部病理学
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Salim Elsayed
Department Of Pathology Osaka City University Medical School
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Nakamura Takahiro
Department Of Radiation Biology Graduate School Of Medicine Osaka University
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Hoshi Manabu
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
Department Of Pathology Osaka City University Medical School
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Wanibuchi Hideki
大阪府立成人病センター 分子生物学
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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Hoshi Manabu
Department Of Orthopaedic Surgery Osaka Medical Center For Cancer And Cardiovascular Diseases
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Murai Takashi
Department Pathology Osaka City University Medical School
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Murai Takashi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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Nomura Taisei
Department Of Radiation Biology And Medical Genetics Graduate School Of Medicine Osaka University
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Wanibuchi H
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Takaoka Kunio
Department Of Anesthesiology Osaka City University Graduate School Of Medicine
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Takaba Katsumi
Department Of Pathology Osaka City University Medical School
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Wanibuchi Hideki
Department Of Pathology Osaka City University Graduate School Of Medicine
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