MITOGENIC ACTIVITY AND IN VITRO FERTILIZATION INHIBITORY ACTIVITY OF GENYPTERUS BLACODES LECTIN
スポンサーリンク
概要
- 論文の詳細を見る
A lectin which we purified from the mucous of Ophidiidae Genypterus blacodes showed a potent mitogenic activity which was comparable to that of concanavalin A (con A). On the other hand, the lectin treated with 2-mercaptoethanol showed an anti-mitogenic activity against con A and lipopolysaccharide (LPS). Lymphocytes were separated into a T cell rich fraction and B cell rich fraction by soybean agglutinin. The mitogenic activity of G. blacodes lectin was examined using these cells. It was suggested that the mitogenic activity of G. blacodes lectin was based on the stimulation of T cells. The lectin was also subjected to both the sperm agglutination and the in vitro fertilization tests in mouse. It was demonstrated that : a) the lectin receptors were ubiquitous on sperm ; b) in vitro fertilization of mouse ova was completely blocked by the binding of the lectin to the zona pellucida of the ova.
- 公益社団法人日本薬学会の論文
著者
-
TSUJIKAWA KAZUTAKE
Faculty of pharmaceutical Sciences, Osaka University
-
Ichida S
Kinki Univ. Osaka Jpn
-
Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
-
Tsujikawa K
Osaka Univ. Osaka Jpn
-
Mimura T
Faculty Of Pharmaceutical Sciences Osaka University
-
Maeda K
Faculty Of Pharmaceutical Sciences Osaka University
-
AONUMA SHIGERU
Faculty of Pharmaceutical Sciences, Osaka University
-
Mimura Tsutomu
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
-
ODA YASUO
Faculty of Pharmaceutical Sciences, Kinki University
-
ICHIDA SEIJI
Faculty of Pharmaceutical Sciences, Kinki University
-
Tsujikawa Kazutake
Faculty Of Pharmaceutical Sciences Osaka University
-
Maeda K
Faculty Of Agriculture Kochi University
-
Oda Y
Health Sci. Univ. Hokkaido Hokkaido Jpn
-
Takada K
Kyoto Pharmaceutical Univ. Kyoto Jpn
-
Ichida S
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
-
Aonuma Shigeru
Faculty Of Pharmaceutical Sciences Osaka University
-
Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
-
Oda Yasuo
Faculty Of Pharmaceutical Sciences Kinki University
-
Miyamoto T
Faculty Of Pharmaceutical Sciences Osaka University
-
Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
-
Mimura T
Division Of Bio-medical And Immunological Chemistry Faculty Of Pharmaceutical Sciences Osaka Univers
-
Aonuma Shigeru
Faculty of Pharmaceutical Science, Kinki University
関連論文
- Specific Alternation of Rhythm in Temperature (SART) Stress-Induced Irritable Bowel Syndrome-Like Changes in Mice and Effects of Drugs
- Pharmacokinetics of Human Immunodeficiency Virus Protease Inhibitor, Nelfinavir, in Poloxamer 407-Induced Hyperlipidemic Model Rats(Biopharmacy)
- A New Antiarrhythmic Peptide, N-3-(4-Hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly(Biological)
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. V. MECHANISM OF ANTI-INFLAMMATORY ACTION OF CARBOXAMIDE-METHYLATED L-CHAIN (Fr. I-L) AND H-CHAIN (Fr. I-H) FROM HUMAN SERUM IgG.
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. IV. INDUCTION OF ANTIINFLAMMATORY ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IMMUNOGLOBULIN G AND PHARMACOLOG
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. IV. INDUCTION OF ANTIINFLAMMATORY ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IMMUNOGLOBULIN G AND PHARMACOLOG
- Enhancement of Veratridine-Induced Sodium Dynamics in NG108-15 Cells during Differentiation(Pharmacology)
- Pharmacokinetics of FK-506,a Novel Immunosuppressant, after Intravenous and Oral Administrations to Rats
- Biological and Pharmaceutical Factors Affecting the Absorption and Lymphatic Delivery of Ciclosporin A from Gastrointestinal Tract
- STUDIES ON THE PROMOTING EFFECT OF LIPID-SURFACTANT MIXED MICELLES (MM) ON INTESTINAL ABSORPTION OF COLLOIDAL PARTICLES. DEPENDENCE ON PARTICLE SIZE AND ADMINISTRATION SITE
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY FUSOGENIC LIPID AS A MEMBRANE MODIFIER
- THE MODE OF ENHANCED ENTERAL ABSORPTION OF MACROMOLECULES BY LIPID-SURFACTANT MIXED MICELLES I
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY FUSOGENIC LIPID-SURFACTANT MIXED MICELLES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS A POORLY ABBSORBABLE DRUG. III.^ HISTOLOGICAL STUDY AFTER ADDITION OF VARIOUS ABSORPTION PROMOTERS IN RATS
- EFFECT OF ADMINISTRATION ROUTE ON THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS POORLY ABSORBABLE DRUGS. II. STUDY ON THE ABSORPTION PROMOTING EFFECT OF AZONE
- ROLE OF THE DISPERSION SYSTEMS CONTAINING FUSOGENIC LIPIDS ON ENHANCED ABSORPTION OF POORLY ABSORBABLE DRUGS FROM THE GASTROINTESTINAL TRACT
- PROMOTION OF THE SELECTIVE LYMPHATIC DELIVERY OF CYCLOSPORIN A BY LIPID-SURFACTANT MIXED MICELLES
- POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LIPID-SURFACTANT MIXED MICELLES I. IN VIVO AND TUMORNEUTRALIZING ACTIVITY AGAINST MOUSE ETHRLICH ASCITES TUMOR AND RAT ASCITES HEPATOMA AH66
- COMPARISON OF DISAPPEARANCE FROM BLOOD AND LYMPHATIC DELIVERY OF HUMAN FIBROBLAST INTERFERON IN RAT BY DIFFERENT ADMINISTRATION ROUTES
- ENHANCING EFFECT OF ABSORPTION PROMOTERS ON PERCUTANEOUS ABSORPTION OF A MODEL DYE (6-CARBOXYFLUORESCEIN) AS POORLY ABSORBABLE DRUGS. I. COMPARISON OF PLASMA LEVELS AFTER ADDITION OF VARIOUS ABSORPTION PROMOTERS IN RAT
- OPTIMAL DOSAGE REGIMEN CALCULATION BASED ON THE REMAINING DRUG CONCENTRATIONS IN PLASMA
- INTESTINAL ABSORPTION OF CARBOXYFLUORESCEIN ENTRAPPED IN LIPOSOMES IN COMPARISON WITH ITS ADMINISTRATION WITH LIPID-SURFACTANT MIXED MICELLES
- A METHOD TO POTENTIATE ENTERAL ABSORPTION OF INTERFERON AND SELECTIVE DELIVERY INTO LYMPHATICS
- MOLECULAR WIGHT DEPENDENCE OF PERMSELECTIVITY TO RAT SMALL INTESTINAL BLOOD-LYMPH BARRIER FOR EXOGENOUS MACROMOLECULES ABSORBED FROM LUMEN
- PHARMACOKINETIC PROPERTY OF HUMAN INTERFERON AFTER ADMINISTRATION BY DIFFERENT ROUTES : PROMOTION OF INTESTINAL ABSORPTION AND SPECIFIC TRANSFER INTO LYMPHATICS
- Inhibitory Effects of Tetrahydroisoquisoquinoline Derivatives on Ca^ and Na^+Channels in Crude Nerve Endings
- The Inhibitory Effect of the Toxic Fraction from Sea Urchin (Toxopneustes pileolus) Venom on ^Ca^ Uptake in Crude Synaptosome Fraction from Chick Brain
- CAPACITATION INDUCING ACTIVITY OF SERUM ALBUMIN IN FERTILIZATION OF MOUSE OVA IN VITRO
- Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells
- Isolation of immunosuppressive phospholipids from marine bacteria
- Increase of Cytochrome b mRNA by Bis(2-hydroxyethyl) Trisulfide in J774A.1 Cells
- Increase of Migration of Cultured Endothelial Cells by Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle
- BIOLOGICAL ACTIVITY OF ANTITUMOR SUBSTANCE DERIVED FROM BACILLUS STEAROTHERMOPHILUS
- Potent Synthetic Analogues of Angiotensin-converting Enzyme Inhibitor Derived from Tuna Muscle(Biological Chemistry)
- Production of Angiotensin-Converting Enzyme Inhibitors from Baker's Yeast Glyceraldehyde-3-phosphate Dehydrogenase
- Isolation and Identification of Hydroquinone in Baker's Yeast(Biological Chemistry)
- Bacillus stearothermophilus Glyceraldehyde-3-phosphate Dehydrogenase as a Source of Angiotensin-converting Enzyme Inhibitors(Biological Chemistry)
- Enhancement of Heparin-Binding Ability of Fibronectin by S-Carboxamidemethylation
- Studies on Pharmacological Activation of Human Serum Immunoglobulin G by Chemical Modification and Active Subfragments. VIII. Effect of Carboxamide-Methylated Light Chain (Fr. I-L) on Leukocyte Functions
- RESPONSE OF IMMUNOREACTIVE ANTIARRHYTHMIC PEPTIDE (IR-AAP) LEVEL ASSOCIATED WITH EXPERIMENTAL ARRHYTHMIA IN RATS
- POTENT PLATELET ANTIAGGREGANT ACTION OF AN ANTIARRHYTHMIC PEPTIDE (AAP)
- STUDIES ON SPERM CAPACITATION USING MONOCLONAL ANTIBODY - DISAPPEARANCE OF AN ANTIGEN FROM THE ANTERIOR PART OF MOUSE SPERM HEAD
- MITOGENIC ACTIVITY AND IN VITRO FERTILIZATION INHIBITORY ACTIVITY OF GENYPTERUS BLACODES LECTIN
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IMMUNOGLOBULIN G BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. III. MECHANISM OF ANTIULCEROUS ACTION OF ALKYLATED LIGHT CHAIN (Fr.I-L)
- PURIFICATION AND CHARACTERIZATION OF A FISH LECTIN FROM THE EXTERNAL MUCOUS OF OPHIDIIDAE, GENYPTERUS BLACODES
- INHIBITORY EFFECTS OF UNSATURATED FATTY ACIDS OF trans-2-C_ TO trans-2-C_ SEVERAL C_ AND C_ ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS
- HOMOLOGY OF AN ACROSOME-REACTED SPERM-SPECIFIC ANTIGEN TO CD46
- ANGIOTENSIN-CONVERTING ENZYME INHIBITOR CUT OUT OF YEAST GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
- Biological Properties of Angiotensin-Converting Enzyme Inhibitor Derived from Tuna Muscle
- DETERMINATION OF IMMUNOREACTIVE ANTIARRHYTHMIC PEPTIDE (AAP) IN RATS
- Evaluation of Gastrointestinal Transit Characteristics of Oral Patch Preparation Using Caffeine as a Model Drug in Human Volunteers
- Pharmaceutical Approach to HIV Protease Inhibitor Atazanavir for Bioavailability Enhancement Based on Solid Dispersion System(Biopharmacy)
- Inhibition in Vitro Fertilization of Mouse Gametes by Sulfated Sialic Acid Polymers
- Simultaneous determination of nicotinic acid and its metabolites in rat urine by micellar electrokinetic chromatography with photodiode array detection
- Evaluation of Factors to Decrease Bioavailability of Cyclosporin A in Rats with Gentamicin-Induced Acute Renal Failure (Biopharmacy)
- Effect of Indinavir on the Intestinal Exsorption of Amprenavir, Saquinavir and Nelfinavir after Intravenous Administration in Rats
- Properties and Metabolic Diversity of Microbial Communities in Soils Treated with Steam Sterilization Compared with Methyl Bromide and Chloropicrin Fumigations (Soil Biology)
- Green fluorescent protein as a marker in transgenic mice
- Evaluation of Factors to Decrease Plasma Concentration of an HIV Protease Inhibitor, Saquinavir in Ethanol-Treated Rats(Biopharmacy)
- Highly sensitive quantification of vancomycin in plasma samples using liquid chromatography-tandem mass spectrometry and oral bioavailability in rats
- Synthesis and Antitumor Activity of Fused Quinoline Derivatives. IV. Novel 11-Aminoindolo[3,2-b]quinolines
- Relationship between Excretion Clearance of Rhodamine 123 and P-Glycoprotein (Pgp) Expression Induced by Representative Pgp Inducers(Biopharmacy)
- In Vivo Effects of Cyclosporin A and Ketoconazole on the Pharmacokinetics of Representative Substrates for P-Glycoprotein and Cytochrome P450 (CYP) 3A in Rats(Biopharmacy)
- Effect of Chronic Administration of Ritonavir on Function of Cytochrome P450 3A and P-Glycoprotein in Rats(Biopharmacy)
- CONTRIBUTION OF SH-PROTEINS TO PROMOTIVE TRANSMUCOSAL PERMEATION OF POORLY ABSORBABLE DYE WITH OLEATE IN RAT COLON
- Clinical Pharmacokinetics of Mycophenolate Mofetil in Japanese Renal Transplant Recipients : a Retrospective Cohort Study in a Single Center(Biopharmacy)
- Self-Dissolving Micropiles for the Percutaneous Absorption of Recombinant Human Growth Hormone in Rats(Biopharmacy)
- Long-Term Pharmacokinetic Efficacy and Safety of Low-Dose Ritonavir as a Booster and Atazanavir Pharmaceutical Formulation Based on Solid Dispersion System in Rats(Biopharmacy)
- Antihyperglycemic Effect of Insulin from Self-Dissolving Micropiles in Dogs
- Effect of Water Intake on Pharmacokinetics of Lansoprazole from Fast Disintegrating Tablet in Human Subjects
- Evaluation of Fluorescence Polarization Method for Binding Study in Carbohydrate-Lectin Interaction
- EFFECTS OF BRANCHED CHAIN FATTY ACIDS OF Iso-C_ TO Iso-C_ ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. II. INHIBITORY EFFECTS OF CARBOXAMIDEMETHYLATED L CHAIN FROM HUMAN SERUM IgG ON VARIOUS ULCER MODELS AND ITS INHIBITION MECHANISM
- STUDIES ON PHARMACOLOGICAL ACTIVATION OF HUMAN SERUM IgG BY CHEMICAL MODIFICATION AND ACTIVE SUBFRAGMENTS. I. INDUCTION OF ANTI-ULCEROGENIC ACTIVITY BY CHEMICAL CLEAVAGE OF INTERCHAIN DISULFIDE BONDS IN HUMAN IgG AND PROPERTIES OF ACTIVE SUBFRAGMENTS
- Bioequivalence study and evaluation study for absorption from oral cavity of lansoprazole fast disintegrating tablet in healthy subjects
- INCREASE OF ANTI-ULCEROGENIC ACTIVITY BY REDUCTION AND ALKYLATION OF DISULFIDE BONDS OF A GLOBULIN FRACTION FROM BOVINE SERUM
- STUDIES ON ASPIRIN DERIVATIVES WITH VERY LITTLE SIDE EFFECT. IV.^ INHIBITORY EFFECT OF ASPIRIN-ISOPROPYLANTIPYRINE (AIA) ON SEVERAL EXPERIMENTAL THROMBOSES
- STUDIES ON ASPIRIN DERIVATIVES WITH VERY LITTLE SIDE EFFECTS. III. ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM OF TRITIUM-LABELED ASPIRIN-ISOPROPYLANTIPYRINE (AIA) IN RATS
- STUDIES ON HEART. XXI. AMINO ACID SEQUENCE OF ANTIARRHYTHMIC PEPTIDE (AAP) ISOLATED FROM ATRIA
- STUDIES ON ASPIRIN DERIVATIVES WITH VERY LITTLE SIDE EFFECT. II. POTENT PLATELET ANTI-AGGREGANT ACTIVITY AND NO MUTAGENECITY OF ASPIRIN-ISOPROPYLANTIPYRINE (AIA)
- EFFECT OF VERAPAMIL ON 45Ca UPTAKE BY SYNAPTOSOMES
- EFFECT OF NORMAL C_-C_ FATTY ACIDS AND THEIR RELATED COMPOUNDS ON GASTRIC SECRETION AND EXPERIMENTAL ULCERATION IN RATS
- INHIBITORY EFFECTS OF ALKYLATED BENCE-JONES PROTEIN, k-TYPE LIGHT CHAIN, FROM URINE OF A PATIENT WITH MACROGLOBULINEMIA ON GASTRIC JUICE SECRETION AND ULCERATION IN RATS
- BOUND FORMS OF Ca TAKEN UP BY THE SYNAPTIC PLASMA MEMBRANE
- EFFECTS OF SYNAPTIC PLASMA MEMBRANES ON RELEASE OF ACETYLCHOLINE FROM SYNAPTIC VESICLES
- Changes in Characteristics of the Specific Binding of [^3H]LY-278584, a 5-HT_3-Receptor Antagonist, on Differentiated NG108-15 Cells
- MUSCARINIC CHOLINERGIC RECEPTORS IN MAMMALIAN BRAIN: DIFFERENCES BETWEEN BINDINGS OF ACETYLCHOLINE AND ATROPINE
- INHIBITORY EFFECT OF MICROTUBULE-DISRUPTING AGENTS ON POTASSIUM STIMULATED 45Ca UPTAKE BY RAT BRAIN SLICES
- EFFECTS OF Na+ AND OTHER MONOVALENT CATIONS ON Ca-EFFLUX FROM SYNAPTOSOMES
- Effects of La+++, Mn++ and ruthenium red on Mg-Ca-ATPase activity and ATP-dependent Ca-binding of the synaptic plasma membrane.
- L-Methionine enhances the contractile response to norepinephrine of rat vas deferens.
- L-methionine enhances the contractile responses of rat uterine smooth muscle to acetylcholine and high KCl.
- Characteristics of acetylcholine-induced phosphorylase a activity in uterine segments as a substitute for contractile response to acetylcholine.
- Effects of Calcium Channel Agonists (BAYK8644, CGP28392 and YC-170) on 45Ca Uptake by Rat Uterine Segments.
- Enhancement by L-methionine on the contractile response of uterine segments to acetylcholine and high KCl is mainly due to enhancement of Ca uptake.
- General characteristics of the superprecipitation reaction of rat crude uterine myosin B: Effects of L-methionine and/or transmethylation blockers on the reaction.
- Effects of synthetic .OMEGA.-conotoxin on the contractile responses of segments of rat ileum, stomach fundus and uterus and guinea pig taenia coli.
- Effects of Ca Channel Agonists on 45Ca Uptake Differ Depending on the State of NG108-15 Cells. Effects of Ca Channel Agonists on 45Ca Uptake Differ Depending on the State of NG108-15 Cells.
- Enhancement by L-methionine of contractile responses to acetylcholine and high KCl in uterine segment.