EFFECTS OF Na<SUP>+</SUP> AND OTHER MONOVALENT CATIONS ON Ca-EFFLUX FROM SYNAPTOSOMES
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概要
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Effects of monovalent cations on Ca-efflux were examined in rat brain cortex slices, synaptosomes and synaptic plasma membranes. Effluxes of <SUP>45</SUP>Ca from brain slices and synaptosomes were stimulated by Na<SUP>+</SUP> in medium and the effects of Na<SUP>+</SUP> on the <SUP>45</SUP>Ca-effluxes disappeared at low temperature. Furthermore, we observed that Rb<SUP>+</SUP> had more effect than Na<SUP>+</SUP> on <SUP>45</SUP>Ca-efflux from the synaptosomes, while Li<SUP>+</SUP> had less effect. On the other hand, release of <SUP>45</SUP>Ca from the synaptic plasma membranes which had been preincubated with ATP, Mg<SUP>++</SUP> and <SUP>45</SUP>Ca was stimulated by Na<SUP>+</SUP> and Li<SUP>+</SUP>. But Cs<SUP>+</SUP> and Rb<SUP>+</SUP> were less effective on the release. These results indicate occurrence of Na-dependent Ca-efflux at nerve endings. However, the assumption that ATP-dependent Ca-binding with synaptic plasma membranes may be a partial reaction of Ca-efflux was not supported by these experiments.
- 公益社団法人 日本薬理学会の論文
著者
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Matsuda Tomohiro
Department Of Epidemiology National Institute Of Public Health
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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