Antidiuretic Effects of ATP Induced by Microinjection into the Hypothalamic Supraoptic Nucleus in Water-Loaded and Ethanol-Anesthetized Rats.
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概要
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The effects of microinjection of purinoceptor agonists into the hypothalamic supraoptic nucleus (SON) on urination were examined in water-loaded and ethanol-anesthetized rats. Adenosine triphosphate (ATP), but neither adenosine diphosphate (ADP), adenosine monophosphate (AMP) nor adenosine, concentration-dependently decreased the urine outflow with concomitant increase in the urine osmotic pressure. The ED<SUB>50</SUB> value for ATP was approx. 60 nmol. The antidiuretic effect of ATP was blocked either by prior injection of theophylline (an antagonist of the P<SUB>1</SUB>-type purinoceptor) or by intravenous administration of an arginine vasopressin (AVP)-receptor antagonist, <I>d</I>(CH<SUB>2</SUB>)<SUB>5</SUB>-D-Tyr(Et)-valine-arginine-vasopressin (VAVP). These results suggest that ATP injected into the SON has antidiuretic effects due to release of AVP through an activation of theophylline-sensitive purinoceptors.
- 公益社団法人 日本薬理学会の論文
著者
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Tsushima Hiromi
Department Of Cellular And Molecular Pharmacology Nagoya City University Graduate School Of Medical
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Matsuda Tomohiro
Department Of Epidemiology National Institute Of Public Health
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Mori Mayumi
Department Of Anesthesiology School Of Medicine Fukuoka University
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