Effect of vasopressin antagonist on antidiuresis by oxotremorine microinjected into the hypothalamic supraoptic and paraventricular nuclei in a water-loaded and ethanol-anesthetized rat.
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概要
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Microinjection of the muscarinic agonist oxotremorine into the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei which contain cell bodies of vasopressinergic neurons induced potent antidiuretic effects in waterloaded and ethanol-anesthetized rats. The effects included both decreases in urine outflow and increases in urine osmotic pressure. However, no significant changes in various visceral functions other than antidiuresis such as mean blood pressure, heart rate, respiration rate and rectal temperature were observed when oxotremorine was microinjected into the SON. Only a slight change in mean blood pressure (approx. 10 mmHg decrease) was observed by the microinjection into the PVN. Intravenous preinjection of a vasopressin (AVP) V<SUB>1</SUB> V<SUB>2</SUB> antagonist that has one of the most potent V<SUB>2</SUB> (antidiuretic)-antagonist activities, d(CH<SUB>2</SUB>)<SUB>5</SUB>-D-Tyr(Et)VAVP, inhibited nearly completely the antidiuretic effects induced by the microinjection of oxotremorine. The results demonstrated that oxotremorine stimulated muscarinic receptors in the hypothalamic SON and PVN, released AVP and induced an antidiuretic effect through AVP-receptors in the kidney.
- 公益社団法人 日本薬理学会の論文
著者
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Tsushima Hiromi
Department Of Cellular And Molecular Pharmacology Nagoya City University Graduate School Of Medical
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Matsuda Tomohiro
Department Of Epidemiology National Institute Of Public Health
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Mori Mayumi
Department Of Anesthesiology School Of Medicine Fukuoka University
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