Effects of Calcium Channel Agonists (BAYK8644, CGP28392 and YC-170) on 45Ca Uptake by Rat Uterine Segments.
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概要
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The characteristics of the stimulating effects of the calcium channel agonists BAY K 8644, CGP28392 and YC-170 on <SUP>45</SUP>Ca uptake by rat uterine segments were investigated. BAY K 8644, CGP28392 and YC-170 caused about 150, 100 and 150% increase, respectively in the <SUP>45</SUP>Ca uptake induced by 20 mM KCl. The ED<SUB>50</SUB> values of BAY K 8644, CGP28392 and YC-170 were 1.8 × 10<SUP>-9</SUP>, 2.5 × 10<SUP>-8</SUP> and 9.8 × 10<SUP>-9</SUP> M, respectively. These agonists had little effect on the <SUP>45</SUP>Ca uptake induced by 10<SUP>-6</SUP> M acetylcholine. They also did not affect the basal <SUP>45</SUP>Ca uptake. Their enhancing effects were blocked by the Ca channel antagonist nitrendipine. We conclude that rat uterine segments have voltage-sensitive Ca channels that are stimulated by Ca channel agonists (BAY K 8644, CGP28392 and YC-170) under depolarizing conditions and that the characteristics of the stimulating effects of CGP28392 and YC-170 on <SUP>45</SUP>Ca uptake by rat uterine segments are qualitatively the same as those of BAY K 8644.
- 公益社団法人 日本薬理学会の論文
著者
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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FUJISUE Takashi
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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Ariyoshi Syunji
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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Akimoto Takafumi
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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