Oral Delivery of Synthetic Eel Calcitonin, Elcatonin, in Rats
スポンサーリンク
概要
- 論文の詳細を見る
This study was designed to develop an oral dosage form of elcatonin(EC), a hypocalcemic peptide. The EC absorption was estimated by the reduction in plasma calcium concentrations. When EC was orally coadministered with nitroso-N-acetyl-_<D, L>-penicillamine(SNAP, 4.0mg)and 0.02% Carbopol solution or with taurocholate(20_<mN>)and 0.02% Carbopol solution, the lowering effect was increased compared with that after EC alone, but the F values(0.32 and 0.30%)were extremely small. The oral administration of the mucoadhesive emulsion, which was prepared by coating the W/O/W emulsion with 0.1% Carbopol, enhanced the calcium lowering effect, with the F value of 0.43%. The strong mucoadhesion of the mucoadhesibe emulsion to the gastrointestinal mucosa was obseved. A capsule containing EC(500μg), taurocholate(6mg)and lyphilized Carbopol(3.5mg)administered orally gave a sustained but comparatively small calcium lowering effect. In the in vitro enzymatic hydrolysis experiment, EC was more rapidly hydrolyzed in the intestinal fluid than in the mucosalextract. The combination of 20_<mN> taurocholate with 0.02% Carbopol showed the greatest inhibitory effect in both fluid and extract. These data indicated that EC was effectively absorbed through the intestinal wall, but the peptide was dominantly degraded by proteolytic enzymes in the GI tract. These results will offer a potential approarch to the oral delivery of EC.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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Wada Tetsuyuki
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Faculty Of Pharmaceutical Sciences Kinki University
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Iwaki Masahiro
Dep. Of Pharmacy School Of Pharmacy Kinki Univ.
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Iwaki Masahiro
Faculty Of Pharmaceutical Sciences Kinki University
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OGISO Taro
Faculty of Pharmaceutical Sciences, Kinki University
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TANINO Tadatoshi
Faculty of Pharmaceutical Sciences, Kinki University
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FUNAHASHI Natsuko
Faculty of Pharmaceutical Sciences, Kinki University
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TSUKIOKA Yoshinori
Faculty of Pharmaceutical Sciences, Kinki University
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Tanino Tadatoshi
Department Of Pharmacy Kinki University
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Funahashi Natsuko
Faculty Of Pharmaceutical Sciences Kinki University
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Tsukioka Yoshinori
Faculty Of Pharmaceutical Sciences Kinki University
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Ogiso T
Kinki Univ. Osaka Jpn
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Iwaki M
Department Of Pharmacy Kinki University
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Ogiso Taro
Faculty Of Pharmaceutical Sciences Kinki University
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Tanino T
Department Of Pharmacy Kinki University
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