Inhibitory Effects of Tetrahydroisoquisoquinoline Derivatives on Ca^<2+> and Na^+Channels in Crude Nerve Endings

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概要

• 論文の詳細を見る

• Semi-synthetic tetrahydroisoquinoline derivatives prepared from natural alkaloids, possess Ca^<2+> antagonistic properties. These derivatives significantly blocked KCl-stimulated Ca^<2+> uptake (In chick and rat crude nerve ending) which can be partially inhibited by the selective N-type Ca^<2+> channel blocker ω-conotoxin GVIA or the selective P-type Ca^<2+> channel blocker ω-agatoxin IVA. Moreover, PX42 (10 μM; for the tetrahydroisoquinoline compounds in this study) could inhibit the activity of calmodulin-dependent phosphodiesterase and block veratridine-induced (or tetrodotoxin-sensitive) Na^+ uptake. The possible mechanism(s) of non-selective inhibition of ion channels of PX42 is discussed.

• 社団法人日本薬学会の論文
• 2000-03-01

著者

• Zhang Yu-an

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University

• Zhang Yu-an

  近畿大学 薬 生化

• WADA Tetsuyuki

  Department of Biological Chemistry, School of Pharmaceutical Sciences, Kinki University

• ICHIDA Seiji

  Department of Biological Chemistry, School of Pharmaceutical Sciences, Kinki University

• Ichida S

  Kinki Univ. Osaka Jpn

• Ichida Seiji

  Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University

• Wada Tetsuyuki

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University

• Wada Tetsuyuki

  Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University

• Wada Tetsuyuki

  Faculty Of Pharmaceutical Sciences Kinki University

• ABE Junnichi

  Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kinki University

• XU Guo-you

  Division of Medicinal Chemistry, College of Pharmacy, China Pharmaseutical University

• Xu Guo-you

  Division Of Medicinal Chemistry College Of Pharmacy China Pharmaseutical University

• Abe Junnichi

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University

• Ichida S

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University

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