Inhibitory Effects of Tetrahydroisoquisoquinoline Derivatives on Ca^<2+> and Na^+Channels in Crude Nerve Endings
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概要
- 論文の詳細を見る
Semi-synthetic tetrahydroisoquinoline derivatives prepared from natural alkaloids, possess Ca^<2+> antagonistic properties. These derivatives significantly blocked KCl-stimulated Ca^<2+> uptake (In chick and rat crude nerve ending) which can be partially inhibited by the selective N-type Ca^<2+> channel blocker ω-conotoxin GVIA or the selective P-type Ca^<2+> channel blocker ω-agatoxin IVA. Moreover, PX42 (10 μM; for the tetrahydroisoquinoline compounds in this study) could inhibit the activity of calmodulin-dependent phosphodiesterase and block veratridine-induced (or tetrodotoxin-sensitive) Na^+ uptake. The possible mechanism(s) of non-selective inhibition of ion channels of PX42 is discussed.
- 社団法人日本薬学会の論文
- 2000-03-01
著者
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Zhang Yu-an
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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Zhang Yu-an
近畿大学 薬 生化
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WADA Tetsuyuki
Department of Biological Chemistry, School of Pharmaceutical Sciences, Kinki University
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ICHIDA Seiji
Department of Biological Chemistry, School of Pharmaceutical Sciences, Kinki University
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Ichida S
Kinki Univ. Osaka Jpn
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Wada Tetsuyuki
Faculty Of Pharmaceutical Sciences Kinki University
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ABE Junnichi
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kinki University
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XU Guo-you
Division of Medicinal Chemistry, College of Pharmacy, China Pharmaseutical University
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Xu Guo-you
Division Of Medicinal Chemistry College Of Pharmacy China Pharmaseutical University
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Abe Junnichi
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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Ichida S
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Kinki University
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