Enhancement by L-methionine on the contractile response of uterine segments to acetylcholine and high KCl is mainly due to enhancement of Ca uptake.
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概要
- 論文の詳細を見る
Acetylcholine (ACh)- and high KCI-stimulated <SUP>45</SUP>Ca uptake into rat uterine segments was inhibited by 3-deazaadenosine (3-DAA) plus homocysteine thiolactone (HCTL), and this inhibitory effect was attenuated by L-methionine (LMet). Ca-depleted Ringer solution in which uterine muscle had been incubated with L-Met did not enhance the contractile response of another uterine segment to ACh and high KCI in the presence of 3-DAA plus HCTL. These findings together with previous results suggest that the enhancing effect of L-Met on the contractile responses to ACh and high KCI is mainly due to an increase in Ca<SUP>2+</SUP> uptake into the uterine muscle.
- 公益社団法人 日本薬理学会の論文
著者
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Yoshioka Kazuo
Department Of Pediatrics Kinki University School Of Medicine
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Ariyoshi Shunji
Department Of Pharmacology Saga Medical School
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FUJISUE Takashi
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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ARIYOSHI Shunji
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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