EFFECT OF VERAPAMIL ON <SUP>45</SUP>Ca UPTAKE BY SYNAPTOSOMES
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概要
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The effect of verapamil on K-stimulated <SUP>45</SUP>Ca uptake (the difference between uptake in 60 mM-K<SUB>o</SUB> medium and 5 mM-K<SUB>o</SUB> medium) was studied using a synaptosomal fraction from rat brain. Verapamil inhibited K-stimulated <SUP>45</SUP>Ca uptake, but not <SUP>45</SUP>Ca uptake in 5 mM-K<SUB>o</SUB> media (1 mM- and 0.1 mM-Ca<SUB>o</SUB> media). The concentrations of verapamil inducing 50% inhibition of K-stimulated <SUP>45</SUP>Ca uptake (ID50) in 1 mM- and 0.1 mM-Ca<SUB>o</SUB> media were not significantly different, being about 10<SUP>-4</SUP> M and 2×10<SUP>-4</SUP> M, respectively. Like verapamil, Mn<SUP>++</SUP> inhibited only K-stimulated <SUP>45</SUP>Ca uptake, but its ID50 values in 1 mM- and 0.1 mM-Ca<SUB>o</SUB> media were about 1.7 mM and 0.2 mM, respectively. It is considered from these findings that both verapamil and Mn<SUP>++</SUP> specifically inhibit K-stimulated <SUP>45</SUP>Ca uptake, but that the modalities of their inhibitory effects on K-stimulated <SUP>45</SUP>Ca uptake are different.
- 社団法人 日本薬理学会の論文
著者
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ICHIDA Seiji
Department of Biological Chemistry, School of Pharmaceutical Sciences, Kinki University
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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OKADA Kozo
Department of Physics, Okayama University
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Okada Kozo
Department Of Physics Faculty Of Science Okayama University
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TERAO Motome
Department of Pharmaceutics, Faculty of Pharmacy, Kinki University
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OKADA Kozo
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University
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ICHIDA Seiji
Department of Toxicology, Faculty of Pharmacy, Kinki University
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