EFFECTS OF SYNAPTIC PLASMA MEMBRANES ON RELEASE OF ACETYLCHOLINE FROM SYNAPTIC VESICLES
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概要
- 論文の詳細を見る
The influences of synaptic plasma membranes on release of acetylcholine (ACh) from synaptic vesicles isolated from rat brain were examined. In the presence of ATP, Mg<SUP>++</SUP> and Ca<SUP>++</SUP> but absence of cytoplasm from the nerve endings, the synaptic plasma membranes did not increase ACh release indicating absence of a stimulating factor which is known to be present in the cytoplasm. In presence of ATP, Mg<SUP>++</SUP> Ca<SUP>++</SUP> and the cytoplasm, the synaptic plasma membranes inhibited ACh release from the synaptic vesicles in high K<SUP>+</SUP> medium, though not in high Na<SUP>+</SUP> medium. Binding of Ca<SUP>++</SUP> by the synaptic plasma membranes was dependent on ATP, inhibited by Na<SUP>+</SUP> and stimulated by K<SUP>+</SUP>. Thus, the synaptic plasma membranes may inhibit ACh release in high K<SUP>+</SUP> medium due to reduction in the concentration of free Ca<SUP>++</SUP>.
- 社団法人 日本薬理学会の論文
著者
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Ichida Seiji
Department Of Biological Chemistry School Of Pharmaceutical Sciences Kinki University
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Kuo Che-hui
Department Of Pharmacology Osaka University Medical School
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Yoshida Hiroshi
Department Of Biophysics Graduate School Of Science Kyoto University
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Yoshida Hiroshi
Departmen Of Radiology School Of Medicine Asahikawa Medical University
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KUO Che-Hui
Department of Pharmacology I, Osaka University School of Medicine
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ICHIDA Seiji
Department of Pharmacology I, Osaka University School of Medicine
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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