Mediators of Nonadrenergic, Noncholinergic Relaxation in Longitudinal Muscle of the Intestine of ICR Mice
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概要
- 論文の詳細を見る
Mediators of nonadrenergic, noncholinergic (NANC) relaxation in longitudinal muscle of several regions of ICR mouse intestine were studied. An inhibitor of synthesis of nitric oxide, N^G-nitro-L-arginine (L-NOARG) at 10 μM significantly inhibited NANC relaxations induced by electrical field stimulation (EFS) in the jejunum, ileum, and the proximal and distal colon. Especially in the ileum extent of the inhibition was more than 80%. An antagonist of vasoactive intestinal peptide (VIP) receptors. VIP_<10-28> at 3 μM partially inhibited the EFS-induced relaxations in the jejunum and proximal colon, but very slightly in the distal colon and had no effect in the ileum. An antagonist of pituitary adenylate cyclase activating peptide (PACAP) receptor, PACAP_<6-38> at 3 μM partially inhibited the EFS-induced relaxations in the proximal and distal colon, but not in the jejunum and ileum. Totals of percentages of relaxant components mediated by nitric oxide, VIP and PACAP in every region are roughly equal to a hundred percent. In another series of experiments, EFS-induced relaxations were almost completely inhibited by the treatment of the segments with L-NOARG and VIP_<10-28> in the jejunum, with L-NOARG, VIP_<10-28> and PACAP_<6-38> in the proximal colon, and with L-NOARG and PACP_<6-38> in the distal colon. The present results suggest that nitric oxide solely mediates the relaxation of longitudinal muscle of the ileum of ICR mice, whereas nitric oxide and VIP co-mediate it in the jejunum, nitric oxide, VIP and PACAP in the proximal colon, and nitric oxide and PACAP in the distal colon.
- 日本平滑筋学会の論文
著者
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SATOH Yuji
Department of Medical Technology, Osaka Prefectural College of Health Sciences
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TAKEUCHI Tadayoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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HATA Fumiaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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Hata Fumiaki
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Hata Fumiaki
大阪府立大学 農学生命科学研究科
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OKISHIO Yutaka
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, Osaka Prefe
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NISHIO Hideaki
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Science, Osaka Prefec
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YAMAZAKI Yasuko
Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University
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TAKATSUJI Koichi
Department of Medical Technology, Osaka Prefectural College of Nursing
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Nishio Hideaki
大阪府立大学 農 獣医薬理
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Nishio Hideaki
Departments Of Veterinary Pharmacology College Of Agriculture
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Nishio H
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Okishio Y
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Takatsuji Koichi
Department Of Medical Technology Osaka Prefectural College Of Nursing
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Nishio Hideaki
Department Of Veterinary Pharmacology College Of Agriculture Research Institute For Advanced Science
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Satoh Yuji
Department Of Medical Technology Osaka Prefectural College Of Health Sciences
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Okishio Yutaka
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Yamazaki Yasuko
Department Of Mathematics Faculty Of Science Ochanomizu University
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Yamazaki Yasuko
Department Of Veterinary Pharmacology College Of Agriculture Osaka Prefecture University
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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