Modulation of acetylcholine release from guinea-pig ileum myenteric plexus by arachidonic acid cascade inhibitors.
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概要
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Effects of arachidonic acid and mepacrine on ACh release from guinea-pig ileum myenteric plexus were investigated. Mepacrine (1-8 μM) inhibited the ACh release in a concentration-dependent manner. Arachidonic acid counteracted the inhibitory effect of mepacrine, but PGE<SUB>2</SUB> did not. The inhibition induced by a combination of mepacrine and indomethacin on nicotine-induced ACh release was prevented by arachidonic acid, while that on spontaneous ACh release was prevented by arachidonic acid and PGE<SUB>2</SUB> added simultaneously. The roles of arachidonic acid and PGs in the ACh release will be discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
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