Effect of external Ca2+ on the spontaneous and the various stimuli-induced acetylcholine release from guinea-pig ileum myenteric plexus.
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概要
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Effect of external Ca<SUP>2+</SUP> concentration ([Ca<SUP>2+</SUP>]<SUB>o</SUB>) on spontaneous and various types of stimuli-induced acetylcholine (ACh) release from guinea-pig ileum myenteric plexus was studied. Electrical field stimulation- or high-K<SUP>+</SUP>-induced ACh release increased with the increment of [Ca<SUP>2+</SUP>]<SUB>o</SUB>. On the other hand, the spontaneous and the nicotine-induced ACh release increased up to 0.45 mM [Ca<SUP>2+</SUP>]<SUB>o</SUB> and then declined progressively as [Ca<SUP>2+</SUP>]<SUB>o</SUB> was raised. Qualitatively similar results were obtained with dimethylphenylpirerazinium-, 5-hydroxytryptamine- and substance P-induced ACh release. These results were discussed in terms of the stabilizing effect of Ca<SUP>2+</SUP>.
- 公益社団法人 日本薬理学会の論文
著者
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Yokoyama Keiji
Department Of Gastroenterology And Medicine Fukuoka University Faculty Of Medicine
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Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
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SHIMIZU Mitsuru
Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
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