Cooperation of ATP and norepinephrine in inducing contractile responses in guinea pig vas deferens.
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概要
- 論文の詳細を見る
Stimulation of the hypogastric nerve to the guinea pig vas deferens induced biphasic contraction consisting of a rapid transient phase (mediated by ATP) and a delayed tonic phase (mediated by norepinephrine, NE), whereas stimulations in the presence of selective antagonists caused each contractile phase separately. Stimulation in the absence of antagonist induced a larger rapid transient contraction than that induced by stimulation in the presence of α1-antagonist. Results obtained in separate or simultaneous additions of exogenous ATP and NE showed synergism in the rapid transient contraction. These findings indicate that NE assisted ATP in inducing the hypogastric nerve-mediated contractile response in guinea pig vas deferens, but not vice versa.
著者
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Ishii Toshiaki
Department Of Cardiology Surugadai-nihon University Hospital
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Takeuchi Tadayoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences Osaka Prefect
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Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
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HATA Fumiaki
Department of Pharmacology I, Osaka University School of Medicine
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KISHI Isao
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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