DESCENDING RELEASE OF ACETYLCHOLINE FROM THE LOCALLY DISTENDED GUINEA PIG ILEUM
スポンサーリンク
概要
- 論文の詳細を見る
The effects of local distension of the intestinal wall on the release of acetylcholine (ACh) from the adjacent non-distended part were studied with the segment of isolated guinea pig ileum. Local distension of the intestinal wall induced the increased release of ACh in the distended part and in its anal side but not in its oral side. Such aboral release of ACh by local distension was abolished by tetrodotoxin or atropine in the concentrations which did not block the release in the distended part. When hexamethonium was applied exclusively to the distending part, significant increase of ACh release was observed in both the regions oral to and anal to the distended part. It is suggested that distension stimuli applied to the myenteric plexus are transmitted aborally along the network of the Auerbachs plexus to the anal direction. The release of ACh from the intestine by nicotine or DMPP differed from that occurring during local distension in that the release was localized to the part of the intestine to which the drug was applied.
- 社団法人 日本薬理学会の論文
著者
-
TAKEWAKI Tadashi
Department of Veterinary Physiology, Gifu University
-
YANAGIYA Iwao
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
-
Yanagiya Iwao
Department Of Pharmacology College Of Agriculture
-
Yagasaki Osamu
Department Of Veterinary Pharmacology College Of Agriculture University Of Osaka Prefecture
-
Yagasaki Osamu
Department Of Pharmacology College Of Agriculture
-
TAKEWAKI Tadashi
Department of Veterinary Pharmacology. Faculty of Agriculture, Gifu University
-
TAKEWAKI Tadashi
Department of Pathogenetic Veterinary Science, United Graduate School, Gifu University
関連論文
- Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal
- Participation of ATP in Nonadrenergic, Noncholinergic Relaxation of Longitudinal Muscle of Wistar Rat Jejunum
- Role of the Interstitial Cells Distributed in the Myenteric Plexus in Neural Reflexes in the Mouse Ileum
- Essential Role of the Interstitial Cells of Cajal in Nitric Oxide-Mediated Relaxation of Longitudinal Muscle of the Mouse Ileum
- EFFECT OF METHYLMERCURY ON BEHAVIORS OF MICE WITH DRUG REFERENCES TO CENTRAL CHOLINERGIC SYSTEM
- EFFECTS OF METHYLMERCURY CHLORIDE ON VARIOUS CHOLINERGIC PARAMETERS IN VlTRO
- EFFECTS OF METHYLMERCURY ON CHOLINERGIC SYSTEM OF BRAIN TISSUE in vivo (The 6th Meeting for the Study of Toxic Effect)
- EFFECTS OF HYPOXIA, 2,4-DINITROPHENOL AND OUABAIN ON TWITCH POTENTIATION ELICITED FOLLOWING CONDITIONING PULSES IN THE MOUSE PHRENIC NERVE-DIAPHRAGM PREPARATION
- An Assay of Histamine Applied from the Mucosal Surface of Isolated Intestine
- RELEASE OF PROSTAGLANDINS FROM THE PASSIVELY DISTENDED WALL OF GUINEA PIG SMALL INTESTINE
- INVOLVEMENT OF ADRENERGIC AND SEROTONERGIC NERVOUS MECHANISMS IN ALLETHRIN-INDUCED TREMORS IN MICE
- DO GANGLIOSIDES PLAY A SIGNIFICANT ROLE IN A RECEPTOR SITE FOR TYPE A BOTULINUM TOXIN?
- A PHARMACOLOGICAL ANALYSIS OF ALLETHRIN : INDUCED TREMORS IN MICE
- EVIDENCE OF ASCENDING RELEASE OF ACETYLCHOLINE FROM THE LOCALLY DISTENDED GUINEA PIG ILEUM
- DESCENDING RELEASE OF ACETYLCHOLINE FROM THE LOCALLY DISTENDED GUINEA PIG ILEUM
- CHANGES OF TISSUE ACETYLCHOLINE IN THE DISTENDED INTESTINE
- CALCIUM SOURCE FOR CONTRACTILE RESPONSE OF GUINEA PIG TAENIA CAECUM TO CARBACHOL IN A CALCIUM DEFICIENT, POTASSIUM RICH SOLUTION
- Extension of Time until Cardiac Arrest after Injection of a Lethal Dose of Pentobarbital in the Hibernating Syrian Hamster(Physiology)
- Role of Ca^ Mobilization in Muscarinic Receptor-Mediated Membrane Depolarization in Guinea Pig Ileal Smooth Muscle Cells
- NON-CHOLINERGIC AND NON-ADRENERGIC MECHANISMS IN THE CONTRACTION AND RELAXATION OF THE CHICKEN RECTUM
- NON-CHOLINERGIC, EXCITATORY JUNCTION POTENTIALS IN SMOOTH MUSCLE OF CHICKEN RECTUM
- CALCIUM AND THE CONTRACTILE EFFECT OF CARBACHOL IN THE DEPOLARIZED GUINEA-PIG TAENIA CAECUM
- EFFECTS OF CALCIUM ANTAGONISTS ON CONTRACTILE RESPONSE OF GUINEA-PIG TAENIA CAECUM TO CARBACHOL IN A CALCIUM DEFICIENT, POTASSIUM RICH SOLUTION
- EFFECTS OF LOPERAMIDE ON ACETYLCHOLINE AND PROSTAGLANDIN RELEASE FROM ISOLATED GUINEA PIG ILEUM
- Neuropharmacological effect of methylmercury in mice with special reference to the central cholinergic system.
- A METHOD FOR DIFFERENTIAL MEASUREMENT OF FREE AND BOUND ACETYLCHOLINE IN THE SMALL INTESTINE
- B06 SODIUM SALICYLATE FACILITATES CALCIUM-DEPENDENT RELEASE OF TRANSMITTER AT MOUSE NEUROMUSCULAR JUNCTIONS
- Role of PGE2 in Neurotransmission from Pre- to Post-Ganglionic Hypogastric Nerves of Guinea Pigs.
- Cooperation of ATP and norepinephrine in inducing contractile responses in guinea pig vas deferens.
- Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and Mongolian gerbils.
- Effects of Ca2+ blockers on the various types of stimuli-induced acetylcholine release from guinea pig lleum myenteric plexus.
- The biochemical and ultrastructural examinations in central cholinergic damage of the rat induced by the intraperitoneal administration of AF64A.
- Role of Cyclic AMP in Prostaglandin-Induced Modulation of Acetylcholine Release from the Myenteric Plexus of Guinea Pig Ileum.
- Contribution of external Ca2+ to the modulation by prostaglandin E2 of the release of acetylcholine from the myenteric plexus of guinea pig ileum.
- Effects of H-89, an inhibitor of protein kinase A, on the acetylcholine release from myenteric plexus of guinea pig ileum.
- Effect of external Ca2+ on the spontaneous and the various stimuli-induced acetylcholine release from guinea-pig ileum myenteric plexus.
- Modulation of acetylcholine release from guinea-pig ileum myenteric plexus by arachidonic acid cascade inhibitors.
- Effects of adenylate cyclase inhibitors, phosphodiesterase inhibitors, and dibutyryl cyclic AMP on spontaneous and various stimuli-induced acetylcholine release from guinea pig ileum myenteric plexus.