Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine level reduced by scopolamine, hypoxia and ischemia in the rats and Mongolian gerbils.
スポンサーリンク
概要
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Effects of bifemelane hydrochloride (MCl-2016) on acetylcholine (ACh) level in the cerebral cortex and hippocampus of rats and Mongolian gerbils were examined. In normal rats, MCI-2016 (30 mg/kg, i.p.) slightly increased ACh content in the cerebral cortex. Scopolamine (1 mg/kg, i.p.) or hypoxia (95% N<SUB>2</SUB> +5% O<SUB>2</SUB>, 9 min) decreased ACh level and pretreatment of MCl-2016 attenuated the decrement of ACh level in the rats. ACh level in the brain of Mongolian gerbils was significantly decreased following ligation of bilateral carotid arteries. In this case, MCl-201 6 also attenuated the decrement of ACh level. These results suggest that improvement by MCl-2016 of behavioral impairment observed in the animals treated with scopolamine, hypoxia or ischemia may be, at least partly, attributed to the amelioration of decreased ACh level in the brain.
- 公益社団法人 日本薬理学会の論文
著者
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Yanagiya Iwao
Department Of Pharmacology College Of Agriculture
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TOBE Akihiro
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries Limited
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HONDA Sachiko
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
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SAITO Ken-Ichi
Biosciences Laboratory, Research Center, Mitsubishi Chemical Industries, Ltd.
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YANAGIYA Iwao
Department of Veterinary Pharmacolgy, College of Agriculture, University of Osaka Prefecture
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