EFFECTS OF METHYLMERCURY CHLORIDE ON VARIOUS CHOLINERGIC PARAMETERS IN VlTRO
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概要
- 論文の詳細を見る
The effects of methylmercury chloride and other mercury compounds on cholinergic parameters were studied in vitro. Methylmercury chloride (MMC) and phenylmercury acetate inhibited choline acetyltransferase (ChA)/th 20 μM of I_<50>, and mercury nitrate (MN) with 100 μM of I_<50>. All the three compounds had little effect on cholinesterase activity. MMC inhibited a high affinity choline uptake with 41μM of Ki, as well as a low affinity choline uptake with 250μM of Ki. MMC did not affect a spontaneous and potassium-stimulated ACh release from brain tissue slices incubated in eserinized Krebs-Ringer's solution up to the concentration of 100 μM. It was shown that the organic mercury compounds, such as methylmercury, were potent inhibitors of the choline uptake systems, as well as ChA activity.
- 日本トキシコロジー学会の論文
- 1979-11-15
著者
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KOBAYASHI Haruo
Department of Electronic Engineering, Graduate School of Engineering, Gunma University
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Matsusaka N
Iwate Univ. Morioka Jpn
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MATSUSAKA Naonori
Departments of Veterinary Pharmacology and Veterinary Public Health, Iwate University,
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Kobayashi Haruo
Department Of Electronic Engineering Faculty Of Engineering Gunma University
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Yuyama Akira
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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TAKENO Kazu
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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YANAGIYA Iwao
Department of Veterinary Pharmacology, College of Agriculture, University of Osaka Prefecture
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Takeno Kazu
Department Of Veterinary Pharmacology College Of Agriculture University Of Osaka Prefecture
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Takeno Kazu
Department Of Pharmacology College Of Agriculture
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Yuyama Akira
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Yanagiya Iwao
Department Of Pharmacology College Of Agriculture
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Matsusaka Naonori
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Yuyama A
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Matsusaka Naonori
Faculty Of Agriculture Iwate University
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KOBAYASHI HARUO
Department of Animal Breeding, Faculty of Agriculture, University of Tokyo
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