BREEDING OF MICE WITH SPONTANEOUS ALVEOLAR FORMATION IN THE MAMMARY GLAND II. RELATIONSHIP BETWEEN THE SPONTANEOUS ALVEOLAR FORMATION AND ESTROUS CYCLE

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Relationship between the spontaneous lobule-alveolar formation and estrous cycle was observed in mice. Sixty-three virgin mice were devided into two groups: 41 mice were caged four and 22 mice were caged singly. Those mice were observed daily vaginal smear, body weight at every 10 days of age, ovarian and uterine weight at autopsy and presence or absence of lobulealveolar formation in the mammary gland. Results obtained are as follows.<BR>1. Most of the positive SAF mice experienced long estrous cycles before the examination of the mammary gland. But 3 out of 63 mice showed the positive SAF without experiencing long estrous cycles and 6 out of 63 mice with long cycles had not showed the positive SAF.<BR>2. The frequency of long estrous cycles and of the positive SAF was much higher in the grouped mice than in the singly caged mice.<BR>3. The vaginae of the positive SAF mice opened somewhat earlier than those of the negative SAF mice.<BR>4. The weight of body, ovary and uterus at autopsy was somewhat heavier in the positive SAF mice than in the negative SAF mice.
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