Lack of Correlation of Organophosphorus-Induced Delayed Neuropathy with Neuropathy Target Esterase in Hens and Japanese Quails

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Chickens are sensitive to organophosphorus-induced delayed neuropathy (OPIDN), while Japanese quail are less sensitive. Birds were treated with an organophosphate (OP), diisopropylfluorophosphate (DFP) or fenthion, and were examined for the activity of neuropathy target esterase (NTE) in their brains and spinal cords 24h later, or for clinical signs of OPIDN for 3 weeks. Some birds were treated with OP and then with phenylmethylsulfonyl fluoride (PMSF), a promoter of OPIDN, and some Japanese quail were treated repeatedly with each OP for one week. The activity of NTE in the brains and spinal cords of hens and quail treated with DFP alone was strongly inhibited. Hens showed characteristic hindlimb paralysis, but quail did not . Birds treated with fenthion alone showed neither reduced NTE activity nor clinical signs. PMSF markedly inhibited NTE activity in both types of birds. Hens treated with DFP plus PMSF developed stronger clinical signs than those treated with DFP alone, while fenthion plus PMSF caused no signs. Quail treated with either OP plus PMSF had no signs. Quail treated repeatedly with DFP but not with fenthion had slight clinical signs. Thus, the inhibition of NTE activity was not linked to the onset of OPIDN.
公益社団法人日本薬学会の論文
1999-08-31