Effects of restricted feeding on blood parameters in pregnant rabbits
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概要
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The effects of restricted feeding (20g/day from gestational day (GD) 6 to 28) on pregnancy outcome and blood parameters were examined in pregnant rabbits. As compared with the group which was allowed free access to diet throughout the gestational period (NT group), the group subjected to restricted feeding (R group) showed significantly lower values in many parameters such as total protein, albumin and triglyceride on GDs 22 and 28, reflecting low nutritive conditions. In addition, there were significant changes in blood coagulation-related parameters, suggesting an imbalance between coagulation and anti-coagulation factors. Moreover, abortions occurred in about half of the animals of the R group between GDs 23 and 27. When aborted rabbits were compared with those which could maintain pregnancy under restricted feeding, total protein, albumin, platelets and antithrombin III values and especially blood progesterone concentration were significantly lower in aborted rabbits on GD 22, prior to occurrence of abortion. These results suggested that abortions due to restricted feeding might be brought about by lower nutritive conditions, an imbalance of blood coagulation-related factors and lower blood progesterone concentrations.
- 日本トキシコロジー学会の論文
- 2009-02-01
著者
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MATSUOKA Tetsuya
Kannami Laboratory, Bozo Research Center Inc.
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Miki Yasuhiro
Kannami Lab. Bozo Research Center Inc.
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MIZOGUCHI Yasumoto
Kannami Laboratory, Bozo Research Center Inc.
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MIZUGUCHI Hiroyasu
Kannami Laboratory, Bozo Research Center Inc.
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FUKUDA Kazuya
Kannami Laboratory, Bozo Research Center Inc.
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ASANO Yuzo
Kannami Laboratory, Bozo Research Center Inc.
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Endho Takako
Kannami Laboratory Bozo Research Center Inc.
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Kamata Ryo
Kannami Laboratory, Bozo Research Center Inc.
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Ishikawa Tsutomu
Kannami Laboratory, Bozo Research Center Inc.
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Matsuoka Tetsuya
Kannami Laboratory Bozo Research Center Inc.
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Mizoguchi Yasumoto
Kannami Laboratory Bozo Research Center Inc.
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Mizoguchi Yasumoto
Kannami Laboratories Bozo Research Center Inc.
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Mizuguchi Hiroyasu
Kannami Lab. Bozo Res. Center Inc. Jpn
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Mizuguchi Hiroyasu
Kannami Laboratory Bozo Research Center Inc.
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ISHIKURA Toshikazu
Kannami Laboratory, Bozo Research Center Inc.
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Fukuda Kazuya
Kannami Laboratory Bozo Research Center Inc.
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Asano Yuzo
Kannami Laboratory Bozo Research Center Inc.
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Kamata Ryo
Kannami Laboratory Bozo Research Center Inc.
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Ishikawa Tsutomu
Kannami Lab. Bozo Res. Center Inc.
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Kamata R
Kannami Laboratory Bozo Research Center Inc.
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Matsuoka Tetsuya
Kannami Lab. Bozo Res. Center Inc.
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