RELATIONSHIP BETWEEN CAFFEINE-INDUCED OCULAR HYPERTENSION AND ULTRASTRUCTURE CHANGES OF NON-PIGMENTED CILIARY EPITHELIAL CELLS IN RATS
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概要
- 論文の詳細を見る
The purpose of this study was to morphologically assess a possible mechanism for caffeine-induced ocular hypertension. Taking into consideration the relationship between the secretion of aqueous humor and the ultrastructure of the ciliary body, the time course of the morphological features in the ciliary epithelium when caffeine was administered intravenously to male Wistar rats was investigated by electron-microscopy. These morphological findings were also compared with the changes in the intraocular pressure (IOP). A significant increase in IOP was noted 15 min and 1 hr after a single dosing of caffeine alone. This change disappeared in all animals within 2 hr after dosing. The IOP in the animals receiving caffeine and the β-blocker befunolol, which lowers the IOP by inhibiting aqueous humor secretion, decreased significantly from 15 min after dosing, and this change persisted 2 hr after dosing. In electron-microscopy 15 min and/or 1 hr after dosing with caffeine, a slight dilatation in the lateral intercellular spaces near the basement membrane of the non-pigmented ciliary epithelium was observed and the interdigitations between the non-pigmented epithelial cells were intact. Reversal of these changes was observed 2 hr after dosing. On the other hand, the lateral intercellular spaces between the non-pigmented epithelial cells were markedly dilated and the interdigitations were disorganized following dosing with caffeine alone and in combination with befunolol. These results described here indicate that the intravenous administration of caffeine causes ocular hypertension and also changes in the non-pigmented ciliary epithelium, suggesting an enhancement of aqueous humor transportation. This paradigm in the rat is considered to be useful to further assess caffeine-induced ocular hypertension and for use as an animal model in glaucoma research associated with an aqueous humor secretion.
- 日本トキシコロジー学会の論文
- 1997-12-15
著者
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ANDO Takao
Drug Safety Reseatch Laboratories, Pharmaceutical Debelopment Division, Takeda Chemical Industries
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SUZUKI Tadahiko
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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Kurata K
Univ. Tokyo Tokyo Jpn
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Kurata Kazuyuki
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
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Maeda Masayasu
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
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Nishida Eiji
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
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Tsukuda Ryoichi
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
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Suzuki Tsuyoshi
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
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Tokuriki Mikihiko
Laboratory of Veterinary Physiology Yamaguchi University
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Maeda Masayasu
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Nishida Eiji
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Tsukuda Ryoichi
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Ando T
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Kurata Kazuyuki
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Suzuki Tsuyoshi
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Tsukuda R
Takeda Chemical Ind. Ltd. Osaka Jpn
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Kurata K
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Suzuki Tadahiko
Department Of Veterinary Pharmacology Faculty Fo Agriculture Iwate University
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Ando Takao
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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Suzuki Tsuyoshi
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
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