Malignant Transformation of T-cell Large Granular Lymphocyte Leukemia in a Dog

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概要

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• An 8-year-old spayed female Golden Retriever was referred to us for evaluation of mild lymphocytosis. The peripheral lymphocytes were comprised of mostly large granular lymphocytes (LGLs), and flow cytometry showed that they were mostly CD3+8+ T lymphocytes. Clonal rearrangement of the T-cell receptor gene was identified in the peripheral blood, and the dog was therefore diagnosed with LGL chronic leukemia. The dog was subclinical without treatment until hospitalization on day 154, at which point the lymphocytes looked like lymphoblasts and the surface markers changed to CD3-8-. This was regarded as malignant transformation from LGL chronic leukemia to the acute type. Sequential chemotherapy was started, but the dog died on day 190. Necropsy revealed tumor cell infiltration into the heart, skin, and brain.

著者

• TAKAHASHI Tomoko

  Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Scienc

• Kanayama Kiichi

  Laboratory Of Veterinary Physiology Graduate School Of Veterinary Medicine Nihon University

• Watari Toshihiro

  Laboratory Comprehensive Veterinary Clinical Studies Nihon University School Of Veterinary Medicine

• Tokuriki Mikihiko

  Laboratory of Veterinary Physiology Yamaguchi University

• KOIE Hiroshi

  Laboratory of Comprehensive Veterinary Clinical Studies

• Yamaya Yoshiki

  Laboratory Of Veteriary Surgery College Of Bioresourse Sciences Nihon University

• Sato Tsuneo

  Laboratory of Marine Biochemistry, Graduate School of Agricultural Science, Tohoku University,

• OKUDA Masaru

  Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan

• SAKAI Manabu

  Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University

• OKUDA Masaru

  Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

• OTANI Isao

  Laboratory of Veterinary Physiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

• INOUE Masashi

  Animal Medical Center, Nihon University

• ITO Kanako

  Animal Medical Center, Nihon University

• YAMAYA Yoshiki

  Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

• SAKAI Manabu

  Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University

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