EVALUATION OF PERKIN'S APPLANATION TONOMETER AND THE NORMAL RANGE OF INTRAOCULAR PRESSURE IN ANESTHETIZED RATS
スポンサーリンク
概要
- 論文の詳細を見る
To assess the reliability of noninvasive measurement of intraocular pressure (IOP) in rats, a Perkin's applanation tonometer was calibrated against direct manometry. The normal values of IOP in male Wistar rats were then detected. The mean tonometer readings against the transducer IOP produced regression formula: y=-0.198+1.071x (r^2=0.987). The mean IOP with standard deviation in rats was 17.7±3.5 mm Hg (95% and 99% confidence intervals: 17.2 and 18.1 mm Hg, 17.0 and 18.3 mm Hg for the lower and upper limits of the normal rat IOP, respectively). The IOP could be measured accurately using Perkin's applanation tonometer in anesthetized rats each weighing 300 g and over. Measurement of IOP using this tonometer was considered to be valuable allowing, repeated use in rats because of its smal1 size, portability and noninvasiveness.
- 日本トキシコロジー学会の論文
- 1996-11-25
著者
-
Sato Shuzo
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
-
Sato Shuzo
Drug Safery Research Laboratories Takeda Chemical Industries Ltd.
-
SUZUKI Tadahiko
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
-
Kurata K
Univ. Tokyo Tokyo Jpn
-
Kurata Kazuyuki
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
-
Nishida Eiji
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
-
Tsukuda Ryoichi
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
-
Suzuki Tsuyoshi
Drug Safety Research Laboratories Takeda Chemical Industries, Ltd.
-
Nishida Eiji
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
-
Tsukuda Ryoichi
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
-
Kurata Kazuyuki
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
-
Suzuki Tsuyoshi
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
-
Tsukuda R
Takeda Chemical Ind. Ltd. Osaka Jpn
-
Kurata K
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
-
Suzuki Tadahiko
Department Of Veterinary Pharmacology Faculty Fo Agriculture Iwate University
-
Suzuki Tsuyoshi
Drug Safety Research Laboratories Takeda Chemical Industries Ltd.
関連論文
- EFFECTS OF FORMALIN-PRESERVATION ON ELEMENT CONCENTRATIONS IN ANIMAL TISSUES
- O-27 Effects of pyrethroids on striatal dopamine and serotonin release in freely moving rats(CENTRAL NERVOUS AND CIRCULATORY SYSTEM)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-response relationship of N-methyl-N-nitrosourea in inducing micrencephaly in mouse off-spring (NEREVOUS SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Lack of Correlation of Organophosphorus-Induced Delayed Neuropathy with Neuropathy Target Esterase in Hens and Japanese Quails
- RECENT PROGRESS IN THE NEUROTOXICOLOGY OF NATURAL DRUGS ASSOCIATED WITH DEPENDENCE OR ADDICTION, THEIR ENDOGENOUS AGONISTS AND RECEPTORS
- RECENT PROGRESS IN THE NEUROTOXICOLOGY OF NATURAL DRUGS ASSOCIATED WITH DEPENDENCE OR ADDICTION, THEIR ENDOGENOUS AGONISTS AND RECEPTORS
- Brain Regional Cholinergic Activities in Rats Prenatally Treated with a Microencephalic
- Actin-Depolymerizing Effect of Dimeric Macrolides, Bistheonellide A and Swinholide A^1
- 2B-16 Organophosphorus-induced Delayed Neurotoxicity: Specific Binding of [^3H] diisopropylfluorophosphate (DFP) to Chicken Brain and Spinal Cord Preparations.
- "P-63 The correlation of organophosphorus-induced delayed neuropathy with neuropathy target esterase.
- Effects of Tri :, Di : and Monobutyltin on Synaptic Parameters of the Cholinergic System in the Cerebral Cortex of Mice
- A METHOD OF PHYSICAL DEPENDENCY TESTING IN RATS INVOLVING DIETARY ADMINISTRATION
- Tolerant phenomena and muscarinic receptor subtypes in rats treated repeatedly with anticholinesterases.
- COMPLEMENTARY IMPROVEMENT OF THE METHOD FOR DETERMINING CHOLINERGIC ACTIVITIES IN THE SMALL INTESTINE AND ITS APPLICATION TO EXPERIMENTS IN VIVO
- RELATIONSHIP BETWEEN CAFFEINE-INDUCED OCULAR HYPERTENSION AND ULTRASTRUCTURE CHANGES OF NON-PIGMENTED CILIARY EPITHELIAL CELLS IN RATS
- EVALUATION OF PERKIN'S APPLANATION TONOMETER AND THE NORMAL RANGE OF INTRAOCULAR PRESSURE IN ANESTHETIZED RATS
- A procedure for recording electroretinogram (ERG) and effect of sodium iodate on ERG in mice.
- "P-73 A PROCEDURE FOR RECORDING ELECTRORETINOGRAM (ERG) IN MICE (2) : EFFECT OF MONOIODOACETIC ACID ON ERG IN PIGMENTED MICE
- EFFECTS OF SODIUM IODATE ON ELECTRORETINOGRAM IN RATS
- Influence of Age, Sex, Strain and Feeding on the Plasma Erythropoietin Level in Rats
- 212 EFFECTS OF ANTIMONY COMPOUNDS ON CHOLINERGIC ACTIVITIES IN BRAIN TISSUE
- 204 EFFECTS OF THALLIUM COMPOUNDS ON CHOLINERGIC ACTIVITIES IN BRAIN TISSUE
- Dual Distinct Effects of HEMF, A Flavor Component of Soy Sauce on Benzo[a]pyrene-induced Back-mutation in Salmonella Typhimurium (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- EFFECTS OF TRIPHENYLTIN ON CHOLINERGIC ACTIVITIES IN BRAIN TISSUE
- 骨粗鬆症モデルマウスSAMP6におけるFGF-2投与による骨内膜モデリング促進作用
- INFLUENCE OF TRIBUTYLTIN ON CHOLINERGIC ACTIVITIES IN BRAIN TISSUE IN VIVO AND IN VITRO
- P-82 Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. : Fadrozole hydrochloride : An oral 2/4-week male reproductive organ toxicity study(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 4)FADROZOLE HYDROCHLORIDE : AN ORAL 2/4-WEEK MALE REPRODUCTIVE ORGAN TOXICITY STUDY
- Relationship between spleen toxicity and PFC response to anticancer agents
- "P-67 Mechanism for the Anemia Induced by Gentamicin in Rats.
- "P-43 Influences of Ether and Carbon Dioxide Anesthesia on Hematology, Blood Chemistry and Drug Disposition in Rats.
- Evaluation of Telemetry for Recording Blood Pressure, Heart Rate, Electrocardiogram and Locomotor Activity in Conscious Beagle Dogs
- AUDITORY BRAINSTEM RESPONSE (ABR) AND EFFECTS OF FUROSEMIDE ON ABR IN CONSCIOUS F344 RATS
- Peripheral 5-HT_4 receptors mediate copper sulfate-induced vomiting in dogs.
- Repeated intraduodenal administration in dogs.
- Circadian rhythms of blood pressure and heart rate measured by telemetry in rats
- 水ストレス下メロン苗の葉色変化の解析
- Frequency Selectivity on Aspirin-Induced Hearing Loss in Rats with Auditory Stimulus-Induced Conditioned Suppression.
- Vagal Afferent Fibers and Peripheral 5-HT3 Receptors Mediate Cisplatin-Induced Emesis in Dogs.