Contribution of Chloride Channel Activation to the Elevated Muscular Tone of the Pulmonary Artery in Monocrotaline-Induced Pulmonary Hypertensive Rats
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概要
- 論文の詳細を見る
In monocrotaline-treated rat pulmonary artery from which endothelium was removed, greater spontaneous muscular tone was observed under resting conditions than in vehicle-treated artery. The aim of the present study was to show the possible contribution of Cl− channels in the mechanism of the elevated tone. Verapamil almost completely inhibited the elevated spontaneous muscular tone by decreasing [Ca2+]i. The elevated muscular tone was also inhibited by 4,4-diisothiocyanato-stilbene-2,2-disulfonic acid (DIDS), a Cl− channel inhibitor. After the inhibition of muscular tone by DIDS, verapamil did not induce further relaxation. Quantitative RT-PCR analysis indicated that the mRNA levels of ClC3 and Ca2+-activated Cl− channels did not change in the pulmonary hypertensive pulmonary artery from those of vehicle-treated rats. These results suggest that the elevated muscular tone observed in the monocrotaline-induced hypertensive pulmonary artery is due to membrane depolarization of smooth muscle cells and that this phenomenon might be mediated by the activation of DIDS-sensitive Cl− channels.
- 社団法人 日本薬理学会の論文
- 2001-07-01
著者
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Murata Takahisa
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
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Hori Masatoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
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Ozaki Hiroshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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Hori M
Leaf Tobacco Research Center Japan Tobacco Inc.:(present Address)laboratory Of Insect Science And Bi
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KARAKI Hideaki
Department of Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The Univer
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Ozaki H
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences University Of
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Ozaki Hiroshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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Kobayashi Haruo
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Hori M
Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University
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NAKAZAWA Hiroshi
Department of Chemistry, Graduate School of Science, Hiroshima University
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Murata Takahisa
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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中沢 浩
大阪市大 大学院理学研究科
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Karaki Hideaki
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Hori Masatoshi
Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University
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Karaki Hideaki
Department Of Veterinary Pharmacology Graduate School Of Agricultural And Life Sciences The Universi
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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Ozaki Hiroshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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Nakazawa Hiroshi
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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